Clinical Evidence on the Potential Beneficial Effects of Probiotics and Prebiotics in Cardiovascular Disease
Round 1
Reviewer 1 Report
Please go thoroughly throughout the guide for authors of International Journal of Molecular Sciences and made necessary corrections to your manuscript and please correct the grammar – same are marked directly in the text.
Line 16: The aim of 16 this study is to examine - I propose: This study aims to examine….
Line 46: that a good – correct that good….
Line 71: S. thermophilis, L. acidophilus LA-5 and B. bifidum – correct S. thermophilis, L. acidophilus LA-5 and B. bifidum - Latin names of bacteria in italics
Line 86: study studied - I propose: study examined
Line 125: …for the maintenance of the barrier function of the gastrointestinal tract... – I propose: ….for the maintenance of the gastrointestinal tract's barrier function....
Line 155: …which makes... – correct ...which make...
Line 157: parasites (for heart infection) smoking, alcoholand diet. – correct: parasites (for heart infection), smoking, alcohol and diet.
Line 158: host health – correct host's health
Line 193: is associated by low-grade – correct is associated with low-grade
Line 231: endotoxaemia - elsewhere in the text is endotoxemia?
Line 237: such cluste – correct: such as a cluste
Line 243: research – correct: researchers
Line 256: treatment – correct: the treatment
Line 275: therapy – correct therapeutic
Line 303: a number of – I propose several
Line 307: the gut microbiota – correct: gut microbiota
Line 321: to inhibit angiotensin – correct: to inhibit the angiotensin
Line 324: There is mounting data suggesting – I propose: Mounting data is suggesting
Line 374: transplantation – correct: the transplantation
Line 385: analogues – I propose analogs
Line 394: have – correct has
Line 412: multiple – I propose numerous
Line 421: diarrhoea – correct diarrhea
Line 429: a number of – I proprose several
Line 441: have – correct has
Author Response
Reviewer 1
We would like to thank the reviewer for their useful comments and suggestions
Please go thoroughly throughout the guide for authors of International Journal of Molecular Sciences and made necessary corrections to your manuscript and please correct the grammar – same are marked directly in the text.
Line 16: The aim of 16 this study is to examine - I propose: This study aims to examine….
It has been corrected
Line 46: that a good – correct that good….
It has been corrected
Line 71: S. thermophilis, L. acidophilus LA-5 and B. bifidum – correct S. thermophilis, L. acidophilus LA-5 and B. bifidum - Latin names of bacteria in italics
It has been corrected
Line 86: study studied - I propose: study examined
It has been corrected
Line 125: …for the maintenance of the barrier function of the gastrointestinal tract... – I propose: ….for the maintenance of the gastrointestinal tract's barrier function....
It has been corrected
Line 155: …which makes... – correct ...which make...
It has been corrected
Line 157: smoking, alcoholand diet. – correct: parasites (for heart infection), smoking, alcohol and diet.
It has been corrected
Line 158: host health – correct host's health
It has been corrected
Line 193: is associated by low-grade – correct is associated with low-grade
It has been corrected
Line 231: endotoxaemia - elsewhere in the text is endotoxemia?
It has been corrected
Line 237: such cluste – correct: such as a cluste
It has been corrected
Line 243: research – correct: researchers
It has been corrected
Line 256: treatment – correct: the treatment
It has been corrected
Line 275: therapy – correct therapeutic
It has been corrected
Line 303: a number of – I propose several
It has been corrected
Line 307: the gut microbiota – correct: gut microbiota
It has been corrected
Line 321: to inhibit angiotensin – correct: to inhibit the angiotensin
It has been corrected
Line 324: There is mounting data suggesting – I propose: Mounting data is suggesting
It has been corrected
Line 374: transplantation – correct: the transplantation
It has been corrected
Line 385: analogues – I propose analogs
It has been corrected
Line 394: have – correct has
It has been corrected
Line 412: multiple – I propose numerous
It has been corrected
Line 421: diarrhoea – correct diarrhea
It has been corrected
Line 429: a number of – I proprose several
It has been corrected
Line 441: have – correct has
It has been corrected
Reviewer 2 Report
This review summarized the potential beneficial effects of probiotics and prebiotics in cardiovascular diseases. The topic is interesting and the paper is well structured. The following issues should be tackled with before the consideration for acceptance.
1. The evidences on the anti-inflammatory, lipids-lowering and anti-oxidant effects of probiotics and prebiotics in CVDs are suggested to include solely in a part as “reduction in the risk factors of CVDs”, instead of in the introduction part.
2. Atherosclerosis is a popular target with intense investigation. Is there any clinical studies regarding the effects of probiotics and prebiotics in atherosclerosis?
3. The authors said the aim was to focus on clinical studies. However, a number of animal studies were included. I recommend to remove them in order to keep the focus.
4. Please check the paper carefully to avoid some minor spelling or language mistakes. For example, in line 123, there was an repeated word “for”.
Author Response
Reviewer 2
We would like to thank the reviewer for their useful comments and suggestionss
- The evidences on the anti-inflammatory, lipids-lowering and anti-oxidant effects of probiotics and prebiotics in CVDs are suggested to include solely in a part as “reduction in the risk factors of CVDs”, instead of in the introduction part.
“Reduction in the risk factors of CVDs” has been included as a separate subsection
- Atherosclerosis is a popular target with intense investigation. Is there any clinical studies regarding the effects of probiotics and prebiotics in atherosclerosis?
“Atherosclerosis” has been included as a separate subsection
- The authors said the aim was to focus on clinical studies. However, a number of animal studies were included. I recommend to remove them in order to keep the focus.
They have been removed
- Please check the paper carefully to avoid some minor spelling or language mistakes. For example, in line 123, there was a repeated word “for”.
The paper has been carefully checked.
