Artificial and Naturally Derived Phospholipidic Bilayers as Smart Coatings of Solid-State Nanoparticles: Current Works and Perspectives in Cancer Therapy

Percivalle, Nicolò Maria; Carofiglio, Marco; Conte, Marzia; Rosso, Giada; Bentivogli, Alessandro; Mesiano, Giulia; Vighetto, Veronica; Cauda, Valentina

doi:10.3390/ijms232415815

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Artificial and Naturally Derived Phospholipidic Bilayers as Smart Coatings of Solid-State Nanoparticles: Current Works and Perspectives in Cancer Therapy

by

Nicolò Maria Percivalle

^†,

Marco Carofiglio

,

Marzia Conte

^†,

Giada Rosso

,

Alessandro Bentivogli

,

Giulia Mesiano

,

Veronica Vighetto

and

Valentina Cauda

^*

Politecnico di Torino, Department of Applied Science and Technology, Corso Duca degli Abruzzi 24, 10129 Torino, Italy

^*

Author to whom correspondence should be addressed.

^†

These authors contributed equally to this work.

Int. J. Mol. Sci. 2022, 23(24), 15815; https://doi.org/10.3390/ijms232415815

Submission received: 27 October 2022 / Revised: 24 November 2022 / Accepted: 8 December 2022 / Published: 13 December 2022

(This article belongs to the Special Issue Lipids as Supporting Therapy in Cancer)

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Abstract

Recent advances in nanomedicine toward cancer treatment have considered exploiting liposomes and extracellular vesicles as effective cargos to deliver therapeutic agents to tumor cells. Meanwhile, solid-state nanoparticles are continuing to attract interest for their great medical potential thanks to their countless properties and possible applications. However, possible drawbacks arising from the use of nanoparticles in nanomedicine, such as the nonspecific uptake of these materials in healthy organs, their aggregation in biological environments and their possible immunogenicity, must be taken into account. Considering these limitations and the intrinsic capability of phospholipidic bilayers to act as a biocompatible shield, their exploitation for effectively encasing solid-state nanoparticles seems a promising strategy to broaden the frontiers of cancer nanomedicine, also providing the possibility to engineer the lipid bilayers to further enhance the therapeutic potential of such nanotools. This work aims to give a comprehensive overview of the latest developments in the use of artificial liposomes and naturally derived extracellular vesicles for the coating of solid-state nanoparticles for cancer treatment, starting from in vitro works until the up-to-date advances and current limitations of these nanopharmaceutics in clinical applications, passing through in vivo and 3D cultures studies.

Keywords: nanoparticles; liposomes; extracellular vesicles; lipidic shell; biomimicking coating; nanomedicine; supported lipid bilayer; cancer therapy; theranostics

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MDPI and ACS Style

Percivalle, N.M.; Carofiglio, M.; Conte, M.; Rosso, G.; Bentivogli, A.; Mesiano, G.; Vighetto, V.; Cauda, V. Artificial and Naturally Derived Phospholipidic Bilayers as Smart Coatings of Solid-State Nanoparticles: Current Works and Perspectives in Cancer Therapy. Int. J. Mol. Sci. 2022, 23, 15815. https://doi.org/10.3390/ijms232415815

AMA Style

Percivalle NM, Carofiglio M, Conte M, Rosso G, Bentivogli A, Mesiano G, Vighetto V, Cauda V. Artificial and Naturally Derived Phospholipidic Bilayers as Smart Coatings of Solid-State Nanoparticles: Current Works and Perspectives in Cancer Therapy. International Journal of Molecular Sciences. 2022; 23(24):15815. https://doi.org/10.3390/ijms232415815

Chicago/Turabian Style

Percivalle, Nicolò Maria, Marco Carofiglio, Marzia Conte, Giada Rosso, Alessandro Bentivogli, Giulia Mesiano, Veronica Vighetto, and Valentina Cauda. 2022. "Artificial and Naturally Derived Phospholipidic Bilayers as Smart Coatings of Solid-State Nanoparticles: Current Works and Perspectives in Cancer Therapy" International Journal of Molecular Sciences 23, no. 24: 15815. https://doi.org/10.3390/ijms232415815

APA Style

Percivalle, N. M., Carofiglio, M., Conte, M., Rosso, G., Bentivogli, A., Mesiano, G., Vighetto, V., & Cauda, V. (2022). Artificial and Naturally Derived Phospholipidic Bilayers as Smart Coatings of Solid-State Nanoparticles: Current Works and Perspectives in Cancer Therapy. International Journal of Molecular Sciences, 23(24), 15815. https://doi.org/10.3390/ijms232415815

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Artificial and Naturally Derived Phospholipidic Bilayers as Smart Coatings of Solid-State Nanoparticles: Current Works and Perspectives in Cancer Therapy

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