Construction and Characterization of Novel Hydrophilic Nanospheres Loaded with Lambda-Cyhalothrin via Ultrasonic Emulsification–Solvent Evaporation
Abstract
:1. Introduction
2. Results and Discussion
2.1. Characterization of the Nanospheres
2.2. Optimization of Preparation Parameters
2.2.1. Effect of PSMA Concentration on Nanosphere Morphology
2.2.2. Effect of Volume Ratio of Oil Phase/Water Phase on Nanosphere Morphology
2.2.3. Effect of Ultrasonic Action Time on Nanosphere Morphology
2.3. Wettability
2.4. Retention and Adhesion
2.5. Release Behavior
2.6. Stability
2.7. Cytotoxicity Test
3. Materials and Methods
3.1. Materials
3.2. Methods
3.2.1. Preparation of Lambda-Cyhalothrin Nanospheres Encapsulated with PSMA
3.2.2. Optimization of Preparation Process
3.2.3. Characterization of PSMA-LC-NS
3.2.4. Wettability Test
3.2.5. Retention Test
3.2.6. In Vitro Release
3.2.7. Stability
3.2.8. Cytotoxicity Test
3.2.9. Statistical Analysis
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
- Fenner, K.; Canonica, S.; Wackett, L.P.; Elser, M. Evaluating Pesticide Degradation in the Environment: Blind Spots and Emerging Opportunities. Science 2013, 341, 752–758. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Campos, E.; Oliveira, J.D.; Fraceto, L.F. Applications of controlled release Systems for Fungicides, herbicides, Acaricides, nutrients and plant growth hormones: A review. Adv. Sci. 2014, 6, 373–387. [Google Scholar] [CrossRef]
- Grillo, R.; Abhilash, P.C.; Fraceto, L.F. Nanotechnology Applied to Bio-Encapsulation of Pesticides. J. Nanosci. Nanotechnol. 2016, 16, 1231–1234. [Google Scholar] [CrossRef] [PubMed]
- Murdande, S.B.; Shah, D.A.; Dave, R.H. Impact of Nanosizing on Solubility and Dissolution Rate of Poorly Soluble pharmaceuticals. J. Pharm. Sci. 2015, 104, 2094–2102. [Google Scholar] [CrossRef] [PubMed]
- Usman, M.; Farooq, M.; Wakeel, A.; Nawaz, A.; Cheema, S.A.; Rehman, H.; Ashraf, I.; Sanaullsh, M. Nanotechnology in agriculture: Current status, challenges and future opportunities. Sci. Total. Environ. 2020, 721, 13778. [Google Scholar] [CrossRef]
- Nisha, R.S.; Anooj, E.S.; Rajendran, K.; Vallinayagam, S. A comprehensive review on regulatory invention of nano pesticides in Agricultural nano formulation and food system. J. Mol. Struct. 2021, 1239, 130517. [Google Scholar] [CrossRef]
- Benelli, G.; Pavela, R.; Maggi, F.; Petrelli, R. Commentary: Making Green Pesticides Greener? The Potential of Plant Products for Nanosynthesis and Pest Control. J. Clust. Sci. 2017, 28, 3–10. [Google Scholar] [CrossRef]
- Khan, M.R.; Rizvi, T.F. Nanotechnology: Scope and application in plant disease management. Plant. Pathol. J. 2014, 13, 214–231. [Google Scholar] [CrossRef] [Green Version]
- Zhao, X.; Cui, H.X.; Wang, Y.; Cui, B.; Zeng, Z.H. Development strategies and prospects of nano-based smart pesticide formulation. J. Agric. Food Chem. 2017, 66, 6504–6512. [Google Scholar] [CrossRef]
- Wang, C.X.; Zhao, X.; Cui, B.; Zeng, Z.H.; Wang, Y.; Sun, C.J.; Guo, L.; Cui, H.X. Preparation and Characterization of Efficient and Safe Lambda-Cyhalothrin Nanoparticles with Tunable Particle Size. Pest. Manag. Sci. 2020, 77, 2078–2086. [Google Scholar] [CrossRef]
- Wang, C.X.; Cui, B.; Zhao, X.; Wang, Y.; Zeng, Z.H.; Sun, C.J.; Yang, D.S.; Liu, G.Q.; Cui, H.X. Optimization and Characterization of Lambda-Cyhalothrin Solid Nanodispersion by Self-Dispersing Method. Pest. Manag. Sci. 2019, 75, 380–389. [Google Scholar] [CrossRef] [PubMed]
- Cui, B.; Feng, L.; Pan, Z.Z.; Yu, M.L.; Zeng, Z.H.; Sun, C.J.; Zhao, X.; Wang, Y.; Cui, H.X. Evaluation of Stability Biological Activity of Solid Nanodispersion of Lambda-Cyhalothrin. PLoS ONE 2015, 10, e0135953. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Shen, Y.; Wang, Y.; Zhao, X.; Sun, C.J.; Cui, B.; Gao, F.; Zeng, Z.H.; Cui, H.X. Preparation and Physicochemical Characteristics of Thermo-Responsive Emamectin Benzoate Microcapsules. Polymers 2017, 9, 418. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- He, C.; Hu, Y.; Yin, L.; Tang, C.; Yin, C. Effects of particle size surface charge on cellular uptake and biodistribution of polymeric nanoparticles. Biomaterials 2010, 31, 3657–3666. [Google Scholar] [CrossRef] [PubMed]
- Yu, M.L.; Sun, C.J.; Xue, Y.M.; Liu, C.; Qiu, D.W.; Cui, B.; Zhang, Y.; Cui, H.X.; Zeng, Z.H. Tannic Acid-Based Nanopesticides Coating with Highly Improved Foliage Adhesion to Enhance Foliar Retention. RSC. Adv. 2019, 9, 27096–27104. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Antoniou, J.; Fei, L.; Majeed, H.; Jing, Q.; Fang, Z. Physicochemical and morphological properties of size-controlled chitosan–tripolyphosphate nanoparticles. Colloid. Surface A 2015, 465, 137–146. [Google Scholar] [CrossRef]
- Wu, C.F.; Jin, Y.H.; Schneider, T.; Burnham, D.R.; Smith, P.D.; Chiu, D.T. Ultrabright and Bioorthogonal Labeling of Cellular Targets Using Semiconducting Polymer Dots and Click Chemistry. Angew. Chem. Int. Ed. 2010, 49, 9436–9440. [Google Scholar] [CrossRef]
- Chen, X.Z.; Liu, Z.H.; Li, R.Q.; Shan, C.Y.; Sun, Y.J. Multicolor Super-resolution Fluorescence Microscopy with Blue and Carmine Small Photoblinking Polymer Dots. ACS. Nano 2017, 11, 8084–8091. [Google Scholar] [CrossRef] [PubMed]
- Zhang, B.; Wang, F.; Zhou, H.; Gao, D.Y.; Yuan, Z.; Wu, C.F.; Zhang, X.J. Polymer Dots Compartmentalized in Liposomes as a Photocatalyst for In Situ Hydrogen Therapy. Angew. Chem. 2019, 131, 2770–2774. [Google Scholar] [CrossRef]
- Wu, C.F.; Hansen, S.J.; Hou, Q.; Yu, J.B.; Zeigler, M.; Jin, Y.H.; Burnham, D.R.; McNeill, J.D.; Olson, J.M.; Chiu, D.T. Design of Highly Emissive Polymer Dot Bioconjugates for In Vivo Tumor Targeting. Angew. Chem. Int. Ed. 2011, 50, 3430–3434. [Google Scholar] [CrossRef]
- Pooja, D.; Tunki, L.; Kulhari, H.; Reddy, B.B.; Sistla, R. Optimization of solid lipid nanoparticles prepared by single emulsification-solvent evaporation method. Data Brief. 2015, 6, 15–19. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Essa, D.; Choonara, Y.E.; Kondiah, P.; Pillay, V. Comparative Nanofabrication of PLGA-Chitosan-PEG Systems Employing Microfluidics and Emulsification Solvent Evaporation Techniques. Polymers 2020, 12, 1882. [Google Scholar] [CrossRef] [PubMed]
- Ahmad, N.; Banala, V.T.; Kushwaha, P.; Kaevande, A.; Sharma, S.; Tripathi, A.; Verma, A.; Trivedi, R.; Mishra, P. Quercetin-loaded solid lipid nanoparticles improve osteoprotective activity in an ovariectomized rat model: A preventive strategy for post-menopausal osteoporosis. RSC Adv. 2016, 6, 97613–97628. [Google Scholar] [CrossRef]
- Okunlola, A.; Ghomorai, T. Development of ibuprofen microspheres using acetylated plantain starches as polymer for sustained release. J. Pharm. Investig. 2017, 48, 551–564. [Google Scholar] [CrossRef]
- Du, X.; Xu, S.H.; Sun, Z.W.; Aa, Y. Effect of the hydrodynamic radius of colloid microspheres on the Estimation of the coagulation rate constant. Acta Phys. Chim. Sin. 2010, 26, 2807–2812. [Google Scholar]
- Zhou, H.; Sun, X.; Zhang, L.; Zhang, P.; Li, J.; Liu, Y.N. Fabrication of biopolymeric complex Coacervation Core micelles for efficient tea polyphenol delivery via a green process. Langmuir 2012, 28, 14553–14561. [Google Scholar] [CrossRef]
- Chingunpitak, J.; Puttipipatkhachorn, S.; Chavalitshewinkoon-Petmitr, P.; Tozuka, Y.; Morib, K.; Yamamoto, K. Formation, physical stability and in vitro antimalarial activity of dihydroartemisinin nanosuspensions obtained by cogrinding method. Drug Dev. Ind. Pharm. 2008, 34, 314–322. [Google Scholar] [CrossRef]
- Karraker, K.A.; Radk, C.J. Disjoining pressures, zeta potentials and surface tensions of aqueous non-ionic surfactant/electrolyte solutions: Theory and comparison to experiment. Adv. Colloid. Interface 2002, 96, 231–264. [Google Scholar] [CrossRef]
- Freitas, S.; Merkle, H.P.; Gander, B. Microencapsulation by solvent extraction/evaporation: Reviewing the state of the art of microsphere preparation process technology. J. Control Release 2005, 102, 313–332. [Google Scholar] [CrossRef]
- Muherei, M.A.; Junin, R. Investigating synergism in critical micelle concentration of anionic-nonionic surfactant mixtures: Surface versusinterfacial tension techniques. Asian J. Appl. Sci. 2009, 2, 115–127. [Google Scholar] [CrossRef] [Green Version]
- Zhang, G.; Jia, X.; Xing, J.; Shen, S.; Bai, R. A Facile and Fast Approach to Coat Various Substrates with Poly (styrene-co-maleicanhydride) and Polyethyleneimine for Oil/Water Separation. Ind. Eng. Chem. Res. 2019, 58, 19475–19485. [Google Scholar] [CrossRef]
- Feizi, F.; Shamsipur, M.; Gholivand, M.B.; Taherpour, A.; Barati, A.; Shamsipur, H.; Mohajerani, E.; Budd, P. Harnessing the enantiomeric recognition ability of hydrophobic polymers of intrinsic microporosity (PIM-1) toward amino acids by converting them into hydrophilic polymer dots. J. Mater. Chem. C 2020, 8, 13827–13835. [Google Scholar] [CrossRef]
- Chen, H.Y.; Zhi, H.; Liang, J.; Yu, M.L.; Zhao, X.; Sun, C.J.; Wang, Y.; Cui, H.X.; Zeng, Z.H. Development of leaf-adhesive pesticide nanocapsules with pH-responsive release to enhance retention time on crop leaves and improve utilization efficiency. J. Mater. Chem. B 2021, 9, 783–792. [Google Scholar] [CrossRef]
- Och, C.J.; Hon, T.; Such, G.K.; Gui, J.W.; Postma, A.; Caruso, F. Dopamine-Mediated Continuous Assembly of Biodegradable Capsules. Chem. Mater. 2012, 23, 3141–3143. [Google Scholar] [CrossRef]
- Moradi, F.G.; Hejazi, M.J.; Hamishehkar, H.; Enayati, A.A. Co-encapsulation of imidacloprid and lambda-cyhalothrin using biocompatible nanocarriers: Characterization and application. Ecotoxicol. Environ. Saf. 2019, 175, 155–163. [Google Scholar] [CrossRef] [PubMed]
- Yilmaz, H.; Enginar, H.; Cifci, C. Microencapsulation of lambda-cyhalothrin with polyurethane-urea and application on peppermint plant leaves containing a two-spotted red spider mite (Tetranychus urticae). J. Taibah. Univ. Sci. 2022, 15, 63–70. [Google Scholar] [CrossRef]
- Wang, J.; Somasundaran, P. Adsorption and conformation of carboxymethyl cellulose at solid-liquid interfaces using spectroscopic, AFM and allied techniques. J. Colloid. Interface Sci. 2005, 291, 75–83. [Google Scholar] [CrossRef]
- Zolnik, B.S.; Burgess, D.J. Evaluation of in vivo–in vitro release of dexamethasone from PLGA microspheres. J. Control. Release 2008, 127, 137–145. [Google Scholar] [CrossRef]
- Freiberg, S.; Zhu, X.X. Polymer microspheres for controlled drug release. Int. J. Pharm. 2004, 282, 1–18. [Google Scholar] [CrossRef]
- Wen, S.; Jinlai, O.U.; Luo, R.; Liang, W.; Ouyang, P.; Zeng, F.; Chen, Y.; Zhenxia, X.U.; Zhao, W.; Sha, L.I. Preparation and Release Behavior of Pectin Nanoparticles Loading Doxorubicin. J. Pharm. Biomed. Sci. 2015, 5, 385–393. [Google Scholar]
- Yao, J.; Zhang, S.; Li, W.; Du, Z.; Li, Y. In vitro drug controlled-release behavior of an electrospun modified poly (lactic acid)/bacitracin drug delivery system. RSC Adv. 2016, 6, 515–521. [Google Scholar] [CrossRef]
- Shawer, R.; Ei-Leithy, E.S.; Abdel-Rashid, R.S.; Eltaweil, A.; Baeshen, R.S.; Mori, N. Preparation of Lambda-Cyhalothrin-Loaded Chitosan Nanoparticles and Their Bioactivity against Drosophila suzukii. Nanomaterials 2022, 12, 3110. [Google Scholar] [CrossRef] [PubMed]
- Yao, J.W.; Cui, B.; Zhao, X.; Zhi, H.; Zeng, Z.H.; Wang, Y.; Sun, C.J.; Liu, G.Q.; Gao, J.M.; Cui, H.X. Antagonistic Effect of Azoxystrobin Poly (Lactic Acid) Microspheres with Controllable Particle Size on Colletotrichum higginsianum Sacc. Nanomaterials 2018, 8, 857. [Google Scholar] [CrossRef] [PubMed] [Green Version]
- Zhang, J.; Zhao, C.; Liu, Y.; Cao, L.; Wu, Y.; Huang, Q. Size-Dependent Effect of Prochloraz-Loaded mPEG-PLGA Micro and Nanoparticles. J. Nanosci. Nanotechnol. 2016, 16, 6231–6237. [Google Scholar] [CrossRef]
- Li, F.; Zhu, A.; Song, X.; Ji, L. Novel surfactant for preparation of poly (L-lactic acid) nanoparticles with controllable release profile and cytocompatibility for drug delivery. Colloids Surf. B 2014, 115, 377–383. [Google Scholar] [CrossRef]
- Chan, H.K.; Kwok, P. Nanotechnology versus other techniques in improving drug dissolution. Curr. Pharm. Des. 2014, 20, 474–482. [Google Scholar]
- Ni, D.R.; Wu, B.X.; Li, X.H. Discussion on the factors influencing the stability of solid preparation and its improvement method. Chin. Healthc. Innov. 2007, 2, 103–104. [Google Scholar]
- Luckham, P.F. Physical stability of suspension concentrates with particular reference to pharmaceutical and pesticide formulations. Pest. Manag. Sci. 2010, 25, 25–34. [Google Scholar] [CrossRef]
- Wu, L.; Zhang, J.; Watanabe, W. Physical and chemical stability of drug nanoparticles. Adv. Drug Deliv. Rev. 2011, 63, 456–469. [Google Scholar] [CrossRef]
- Song, S.; Liu, X.; Jiang, J.; Qian, Y. Stability of triazophos in self-nanoemulsifying pesticide delivery system. Colloid. Surf. A 2009, 350, 57–62. [Google Scholar] [CrossRef]
Samples | Mean Particle Size (nm) | Zeta Potential (mV) |
---|---|---|
PSMA-LC-NS | 105 ± 0.6 | −31.5 |
lambda-cyhalothrin particles | 248 ± 5.6 | −16.5 |
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. |
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
Share and Cite
Wang, C.; Wang, M.; Wang, Y.; Pan, J.; Sun, C.; Zeng, Z.; Ren, S.; Cui, H.; Zhao, X. Construction and Characterization of Novel Hydrophilic Nanospheres Loaded with Lambda-Cyhalothrin via Ultrasonic Emulsification–Solvent Evaporation. Int. J. Mol. Sci. 2022, 23, 14063. https://doi.org/10.3390/ijms232214063
Wang C, Wang M, Wang Y, Pan J, Sun C, Zeng Z, Ren S, Cui H, Zhao X. Construction and Characterization of Novel Hydrophilic Nanospheres Loaded with Lambda-Cyhalothrin via Ultrasonic Emulsification–Solvent Evaporation. International Journal of Molecular Sciences. 2022; 23(22):14063. https://doi.org/10.3390/ijms232214063
Chicago/Turabian StyleWang, Chunxin, Mengjie Wang, Yan Wang, Junqian Pan, Changjiao Sun, Zhanghua Zeng, Shuaikai Ren, Haixin Cui, and Xiang Zhao. 2022. "Construction and Characterization of Novel Hydrophilic Nanospheres Loaded with Lambda-Cyhalothrin via Ultrasonic Emulsification–Solvent Evaporation" International Journal of Molecular Sciences 23, no. 22: 14063. https://doi.org/10.3390/ijms232214063