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Volume 23
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10.3390/ijms231911304
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Article

PIKE-A Modulates Mitochondrial Metabolism through Increasing SDHA Expression Mediated by STAT3/FTO Axis

by
Mingming Sun
1,
Qi Yan
1,
Yaya Qiao
1,
Huifang Zhao
2,
Yingzhi Wang
1,
Changliang Shan
1,* and
Shuai Zhang
2,*
1
State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300350, China
2
School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2022, 23(19), 11304; https://doi.org/10.3390/ijms231911304
Submission received: 29 June 2022 / Revised: 16 September 2022 / Accepted: 22 September 2022 / Published: 25 September 2022
(This article belongs to the Collection Feature Papers in Molecular Oncology)
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Abstract

Previous studies have shown that phosphoinositide 3-kinase enhancer-activating Akt (PIKE-A) is involved in the regulation of several biological processes in cancer. In our previous study, we demonstrated a crucial function of PIKE-A in cancer energy metabolism by regulating pentose phosphate pathway (PPP) flux. However, whether PIKE-A regulates energy metabolism through affecting mitochondrial changes are poorly understood. In the present study, we show that PIKE-A promotes mitochondrial membrane potential, leading to increasing proliferation of glioblastoma cell. Mechanistically, PIKE-A affects the expression of respiratory chain complex Ⅱ succinate dehydrogenase A (SDHA), mediated by regulating the axis of STAT3/FTO. Taken together, these results revealed that inhibition of PIKE-A reduced STAT3/FTO/SDHA expression, leading to the suppression of mitochondrial function. Thus, our findings suggest the PIKE-A/STAT3/FTO/SDHA axis as promising anti-cancer treatment targets.
Keywords: PIKE-A; mitochondria; SDHA; cell proliferation; glioblastoma PIKE-A; mitochondria; SDHA; cell proliferation; glioblastoma

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MDPI and ACS Style

Sun, M.; Yan, Q.; Qiao, Y.; Zhao, H.; Wang, Y.; Shan, C.; Zhang, S. PIKE-A Modulates Mitochondrial Metabolism through Increasing SDHA Expression Mediated by STAT3/FTO Axis. Int. J. Mol. Sci. 2022, 23, 11304. https://doi.org/10.3390/ijms231911304

AMA Style

Sun M, Yan Q, Qiao Y, Zhao H, Wang Y, Shan C, Zhang S. PIKE-A Modulates Mitochondrial Metabolism through Increasing SDHA Expression Mediated by STAT3/FTO Axis. International Journal of Molecular Sciences. 2022; 23(19):11304. https://doi.org/10.3390/ijms231911304

Chicago/Turabian Style

Sun, Mingming, Qi Yan, Yaya Qiao, Huifang Zhao, Yingzhi Wang, Changliang Shan, and Shuai Zhang. 2022. "PIKE-A Modulates Mitochondrial Metabolism through Increasing SDHA Expression Mediated by STAT3/FTO Axis" International Journal of Molecular Sciences 23, no. 19: 11304. https://doi.org/10.3390/ijms231911304

APA Style

Sun, M., Yan, Q., Qiao, Y., Zhao, H., Wang, Y., Shan, C., & Zhang, S. (2022). PIKE-A Modulates Mitochondrial Metabolism through Increasing SDHA Expression Mediated by STAT3/FTO Axis. International Journal of Molecular Sciences, 23(19), 11304. https://doi.org/10.3390/ijms231911304

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