Dipeptide IF and Exercise Training Attenuate Hypertension in SHR Rats by Inhibiting Fibrosis and Hypertrophy and Activating AMPKα1, SIRT1, and PGC1α
Abstract
:1. Introduction
2. Results
2.1. Effect of IF Peptide and Exercise Training on Heart Weight, Blood Lipid Profile, Blood Pressure Ejection Fraction, and Fractional Shortening Parameters in Hypertension Rats
2.2. Effect of IF Peptide and Exercise on Heart, Liver, and Kidney Functional Markers
2.3. Effect of IF Peptide and Exercise Training on Histological Changes in Heart Morphology of Hypertension Rats
2.4. IF Treatment and Exercise Prevent Fibrosis in SHR Rats
2.5. Role of IF Peptide and Exercise Training in Alleviating Hypertrophy-Mediated Inflammation in Hypertensive Rats
2.6. Effect of IF and Exercise Training on the Cell Survival Pathway in the Heart Tissue of SHR Animals
2.7. IF Treatment Combined with Exercise Training Alleviates Hypertension through Upregulating AMPKα1, SIRT1, and PGC1α Signaling Pathways
3. Discussion
4. Materials and Methods
4.1. Chemicals
4.2. Animals
4.3. Treatment Schedule
4.4. Blood Pressure Measurement
4.5. Measurement of Blood Serum Biochemical Parameters
4.6. Echocardiography
4.7. Histology Staining
4.8. Western Blot
4.9. Statistical Analysis
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Ho, J.-H.; Baskaran, R.; Wang, M.-F.; Mohammedsaleh, Z.M.; Yang, H.-S.; Balasubramanian, B.; Lin, W.-T. Dipeptide IF and Exercise Training Attenuate Hypertension in SHR Rats by Inhibiting Fibrosis and Hypertrophy and Activating AMPKα1, SIRT1, and PGC1α. Int. J. Mol. Sci. 2022, 23, 8167. https://doi.org/10.3390/ijms23158167
Ho J-H, Baskaran R, Wang M-F, Mohammedsaleh ZM, Yang H-S, Balasubramanian B, Lin W-T. Dipeptide IF and Exercise Training Attenuate Hypertension in SHR Rats by Inhibiting Fibrosis and Hypertrophy and Activating AMPKα1, SIRT1, and PGC1α. International Journal of Molecular Sciences. 2022; 23(15):8167. https://doi.org/10.3390/ijms23158167
Chicago/Turabian StyleHo, Jou-Hsuan, Rathinasamy Baskaran, Ming-Fu Wang, Zuhair M. Mohammedsaleh, Hong-Siang Yang, Balamuralikrishnan Balasubramanian, and Wan-Teng Lin. 2022. "Dipeptide IF and Exercise Training Attenuate Hypertension in SHR Rats by Inhibiting Fibrosis and Hypertrophy and Activating AMPKα1, SIRT1, and PGC1α" International Journal of Molecular Sciences 23, no. 15: 8167. https://doi.org/10.3390/ijms23158167