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Article

The Rice Malectin Regulates Plant Cell Death and Disease Resistance by Participating in Glycoprotein Quality Control

1
State Key Laboratory of Agrobiotechnology, Beijing 100193, China
2
MOA Key Lab of Pest Monitoring and Green Management, College of Plant Protection, China Agricultural University, Beijing 100193, China
*
Author to whom correspondence should be addressed.
Academic Editor: Jong Seong Jeon
Int. J. Mol. Sci. 2022, 23(10), 5819; https://doi.org/10.3390/ijms23105819
Received: 28 April 2022 / Revised: 19 May 2022 / Accepted: 20 May 2022 / Published: 22 May 2022
(This article belongs to the Special Issue Molecular Genetics of Rice Disease Resistance)
In animals, malectin is well known to play an essential role in endoplasmic reticulum quality control (ERQC) by interacting with ribophorin I, one unit of the oligosaccharyltransferase (OST) complex. However, the functions of malectin in plants remain largely unknown. Here, we demonstrate the rice OsMLD1 is an ER- and Golgi-associated malectin protein and physically interacts with rice homolog of ribophorin I (OsRpn1), and its disruption leads to spontaneous lesion mimic lesions, enhanced disease resistance, and prolonged ER stress. In addition, there are many more N-glycosites and N-glycoproteins identified from the mld1 mutant than wildtype. Furthermore, OsSERK1 and OsSERK2, which have more N-glycosites in mld1, were demonstrated to interact with OsMLD1. OsMLD1 can suppress OsSERK1- or OsSERK2-induced cell death. Thus, OsMLD1 may play a similar role to its mammalian homologs in glycoprotein quality control, thereby regulating cell death and immunity of rice, which uncovers the function of malectin in plants. View Full-Text
Keywords: cell death; disease resistance; ER quality control; Oryza sativa; malectin; ribophorin I; OsSERK1; OsSERK2 cell death; disease resistance; ER quality control; Oryza sativa; malectin; ribophorin I; OsSERK1; OsSERK2
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MDPI and ACS Style

Feng, H.; Qiu, T.; Yin, C.; Zhao, X.; Xu, G.; Qi, L.; Zhang, Y.; Peng, Y.; Zhao, W. The Rice Malectin Regulates Plant Cell Death and Disease Resistance by Participating in Glycoprotein Quality Control. Int. J. Mol. Sci. 2022, 23, 5819. https://doi.org/10.3390/ijms23105819

AMA Style

Feng H, Qiu T, Yin C, Zhao X, Xu G, Qi L, Zhang Y, Peng Y, Zhao W. The Rice Malectin Regulates Plant Cell Death and Disease Resistance by Participating in Glycoprotein Quality Control. International Journal of Molecular Sciences. 2022; 23(10):5819. https://doi.org/10.3390/ijms23105819

Chicago/Turabian Style

Feng, Huijing, Tiancheng Qiu, Changfa Yin, Xiaosheng Zhao, Guangyuan Xu, Linlu Qi, Yan Zhang, Youliang Peng, and Wensheng Zhao. 2022. "The Rice Malectin Regulates Plant Cell Death and Disease Resistance by Participating in Glycoprotein Quality Control" International Journal of Molecular Sciences 23, no. 10: 5819. https://doi.org/10.3390/ijms23105819

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