Molecular and Biochemical Mechanism of Cannabidiol in the Management of the Inflammatory and Oxidative Processes Associated with Endometriosis
Abstract
:1. Introduction
2. Results
2.1. Effect of CBD Administration on Endometriotic Lesions
2.2. Effect of CBD Administration on Oxidative Stress Associated with Endometriosis
2.3. Effect of CBD Administration on Fibrosis Associated with Endometriosis
2.4. Effect of CBD Administration on Inflammation with Endometriosis
2.5. Effect of CBD Administration on Mast Cells Recruitment and Pain-Related Mediators Associated with Endometriosis
2.6. Effect of CBD Administration on Pain Sensitivity Threshold Associated with Endometriosis
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Endometriosis Induction
4.3. Experimental Groups
- (1)
- Endometriosis group: animals were subjected to the experimental protocol as already described, and vehicle (ethanol/Tween 80/0.9% saline (3:1:16)) was orally administered on the 7th day and for the next 7 days;
- (2)
- Endometriosis+CBD group: animals were subjected to the experimental protocol as already described, and CBD at the dose of 10 mg/Kg was orally administered on the 7th day and for the next 7 days;
- (3)
- Sham group: animals were subjected to the same experimental protocol but they were intraperitoneally injected with the equivalent volume of phosphate buffered saline (PBS) along the midventral line instead of endometrial tissue.
4.4. Abdominal High-Frequency Ultrasound
4.5. Behavioral Analyses
4.5.1. Open Field Test
4.5.2. Hot Plate
4.5.3. Elevated plus Maze Test
4.5.4. Acetic-Acid-Induced Abdominal Contractions
4.6. Reduced GSH Levels
4.7. Lipid Peroxidation
4.8. SOD Activity
4.9. Enzyme-Linked Immunosorbent Assay (ELISA)
4.10. Histological Examination
4.11. Immunohistochemical Analysis
4.12. Western Blot Analysis
4.13. Statistical Evaluation
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Genovese, T.; Cordaro, M.; Siracusa, R.; Impellizzeri, D.; Caudullo, S.; Raffone, E.; Macrí, F.; Interdonato, L.; Gugliandolo, E.; Interlandi, C.; et al. Molecular and Biochemical Mechanism of Cannabidiol in the Management of the Inflammatory and Oxidative Processes Associated with Endometriosis. Int. J. Mol. Sci. 2022, 23, 5427. https://doi.org/10.3390/ijms23105427
Genovese T, Cordaro M, Siracusa R, Impellizzeri D, Caudullo S, Raffone E, Macrí F, Interdonato L, Gugliandolo E, Interlandi C, et al. Molecular and Biochemical Mechanism of Cannabidiol in the Management of the Inflammatory and Oxidative Processes Associated with Endometriosis. International Journal of Molecular Sciences. 2022; 23(10):5427. https://doi.org/10.3390/ijms23105427
Chicago/Turabian StyleGenovese, Tiziana, Marika Cordaro, Rosalba Siracusa, Daniela Impellizzeri, Sebastiano Caudullo, Emanuela Raffone, Francesco Macrí, Livia Interdonato, Enrico Gugliandolo, Claudia Interlandi, and et al. 2022. "Molecular and Biochemical Mechanism of Cannabidiol in the Management of the Inflammatory and Oxidative Processes Associated with Endometriosis" International Journal of Molecular Sciences 23, no. 10: 5427. https://doi.org/10.3390/ijms23105427