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Review

Endothelial Glycocalyx as a Regulator of Fibrotic Processes

1
Department of Biomedical Sciences, University of Padova, Viale G. Colombo 3, 35121 Padova, Italy
2
Division of Nephrology and Dialysis, Department of Medicine, Piazzale A. Stefani 1, 37126 Verona, Italy
3
R&D Department, CoreQuest Sagl, Via Cantonale 18, 6928 Manno, Switzerland
*
Authors to whom correspondence should be addressed.
Academic Editor: Hironobu Yamashita
Int. J. Mol. Sci. 2021, 22(6), 2996; https://doi.org/10.3390/ijms22062996
Received: 1 February 2021 / Revised: 2 March 2021 / Accepted: 11 March 2021 / Published: 15 March 2021
(This article belongs to the Special Issue Proteolysis of Extracellular Matrix in Human Disease)
The endothelial glycocalyx, the gel layer covering the endothelium, is composed of glycosaminoglycans, proteoglycans, and adsorbed plasma proteins. This structure modulates vessels’ mechanotransduction, vascular permeability, and leukocyte adhesion. Thus, it regulates several physiological and pathological events. In the present review, we described the mechanisms that disturb glycocalyx stability such as reactive oxygen species, matrix metalloproteinases, and heparanase. We then focused our attention on the role of glycocalyx degradation in the induction of profibrotic events and on the possible pharmacological strategies to preserve this delicate structure. View Full-Text
Keywords: endothelium; glycocalyx; fibrosis endothelium; glycocalyx; fibrosis
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MDPI and ACS Style

Masola, V.; Zaza, G.; Arduini, A.; Onisto, M.; Gambaro, G. Endothelial Glycocalyx as a Regulator of Fibrotic Processes. Int. J. Mol. Sci. 2021, 22, 2996. https://doi.org/10.3390/ijms22062996

AMA Style

Masola V, Zaza G, Arduini A, Onisto M, Gambaro G. Endothelial Glycocalyx as a Regulator of Fibrotic Processes. International Journal of Molecular Sciences. 2021; 22(6):2996. https://doi.org/10.3390/ijms22062996

Chicago/Turabian Style

Masola, Valentina, Gianluigi Zaza, Arduino Arduini, Maurizio Onisto, and Giovanni Gambaro. 2021. "Endothelial Glycocalyx as a Regulator of Fibrotic Processes" International Journal of Molecular Sciences 22, no. 6: 2996. https://doi.org/10.3390/ijms22062996

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