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Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes

1
Multicenter Post Graduation Program in Physiological Sciences, Brazilian Society of Physiology, Federal University of the Valleys of Jequitinhonha and Mucuri, Diamantina, Minas Gerais CEP 39.000-000, Brazil
2
Neuroscience and Exercise Study Group (Grupo de Estudos em Neurociências e Exercício–GENE), Federal University of the Valleys of Jequitinhonha and Mucuri, Diamantina, Minas Gerais CEP 39.000-000, Brazil
3
Post-Graduate Program in Medicine and Health, Faculty of Medicine, Federal University of Bahia, Bahia CEP 40.110-100, Brazil
4
Department of Physical Education in Cardiology, Brazilian Society of Cardiology, Bahia CEP 41.170-130, Brazil
5
Center for Biotechnology and Cell Therapy, São Rafael Hospital, Bahia CEP 41.253-190, Brazil
6
D’Or Institute for Research and Education (IDOR), Rio de Janeiro CEP 22.281-100, Brazil
7
Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ), Bahia CEP 40.296-710, Brazil
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(4), 2199; https://doi.org/10.3390/ijms22042199
Received: 11 November 2020 / Revised: 30 November 2020 / Accepted: 2 December 2020 / Published: 23 February 2021
(This article belongs to the Section Molecular Neurobiology)
Type 2 diabetes mellitus (T2DM) is a metabolic disorder associated with insulin resistance and hyperglycemia. Chronic exposure to a T2DM microenvironment with hyperglycemia, hyperinsulinemia, oxidative stress and increased levels of proinflammatory mediators, has negative consequences to the cardiovascular system and mental health. Therefore, atherosclerotic cardiovascular diseases (CVD) and mental health issues have been strongly associated with T2DM. Lifestyle modifications, including physical exercise training, are necessary to prevent T2DM development and its associated complications. It is widely known that the regular practice of exercise provides several physiological benefits to subjects with T2DM, such as managing glycemic and blood pressure levels. Different types of exercise, from aerobic to resistance training, are effective to improve mental health and cognitive function in T2DM. Irisin is a myokine produced in response to exercise, which has been pointed as a relevant mechanism of action to explain the benefits of exercise on cardiovascular and mental health in T2DM patients. Here, we review emerging clinical and experimental evidence about exercise-linked irisin consequences to cardiovascular and mental health in T2DM. View Full-Text
Keywords: physical activity; insulin resistance; inflammation; cognitive decline; memory; dementia physical activity; insulin resistance; inflammation; cognitive decline; memory; dementia
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MDPI and ACS Style

Sousa, R.A.L.D.; Improta-Caria, A.C.; Souza, B.S.d.F. Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes. Int. J. Mol. Sci. 2021, 22, 2199. https://doi.org/10.3390/ijms22042199

AMA Style

Sousa RALD, Improta-Caria AC, Souza BSdF. Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes. International Journal of Molecular Sciences. 2021; 22(4):2199. https://doi.org/10.3390/ijms22042199

Chicago/Turabian Style

Sousa, Ricardo A.L.D.; Improta-Caria, Alex C.; Souza, Bruno S.d.F. 2021. "Exercise–Linked Irisin: Consequences on Mental and Cardiovascular Health in Type 2 Diabetes" Int. J. Mol. Sci. 22, no. 4: 2199. https://doi.org/10.3390/ijms22042199

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