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Volume 22
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Article

Arsenoplatin-Ferritin Nanocage: Structure and Cytotoxicity

by
Giarita Ferraro
1,*,
Alessandro Pratesi
2,
Damiano Cirri
2,
Paola Imbimbo
3,
Daria Maria Monti
3,
Luigi Messori
1 and
Antonello Merlino
3
1
Department of Chemistry “Ugo Schiff”, University of Florence, Via Della Lastruccia, 3-13, Sesto Fiorentino, 50019 Florence, Italy
2
Department of Chemistry and Industrial Chemistry, University of Pisa, Via Giuseppe Moruzzi 13, 56124 Pisa, Italy
3
Department of Chemical Sciences, University of Naples Federico II, Via Cinthia 21, 80126 Naples, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(4), 1874; https://doi.org/10.3390/ijms22041874
Submission received: 22 December 2020 / Revised: 28 January 2021 / Accepted: 4 February 2021 / Published: 13 February 2021
(This article belongs to the Special Issue Metallodrugs: Mechanisms of Action, Molecular Targets and Biological Activity)
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Abstract

Arsenoplatin-1 (AP-1), the prototype of a novel class of metallodrugs containing a PtAs(OH)2 core, was encapsulated within the apoferritin (AFt) nanocage. UV-Vis absorption spectroscopy and inductively coupled plasma-atomic emission spectroscopy measurements confirmed metallodrug encapsulation and allowed us to determine the average amount of AP-1 trapped inside the cage. The X-ray structure of AP-1-encapsulated AFt was solved at 1.50 Å. Diffraction data revealed that an AP-1 fragment coordinates the side chain of a His residue. The biological activity of AP-1-loaded AFt was comparatively tested on a few representative cancer and non-cancer cell lines. Even though the presence of the cage reduces the overall cytotoxicity of AP-1, it improves its selectivity towards cancer cells.
Keywords: Pt compounds; metal complexes; metallodrugs; As compounds; protein metalation; ferritin encapsulation; anti-cancer activity Pt compounds; metal complexes; metallodrugs; As compounds; protein metalation; ferritin encapsulation; anti-cancer activity

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MDPI and ACS Style

Ferraro, G.; Pratesi, A.; Cirri, D.; Imbimbo, P.; Maria Monti, D.; Messori, L.; Merlino, A. Arsenoplatin-Ferritin Nanocage: Structure and Cytotoxicity. Int. J. Mol. Sci. 2021, 22, 1874. https://doi.org/10.3390/ijms22041874

AMA Style

Ferraro G, Pratesi A, Cirri D, Imbimbo P, Maria Monti D, Messori L, Merlino A. Arsenoplatin-Ferritin Nanocage: Structure and Cytotoxicity. International Journal of Molecular Sciences. 2021; 22(4):1874. https://doi.org/10.3390/ijms22041874

Chicago/Turabian Style

Ferraro, Giarita, Alessandro Pratesi, Damiano Cirri, Paola Imbimbo, Daria Maria Monti, Luigi Messori, and Antonello Merlino. 2021. "Arsenoplatin-Ferritin Nanocage: Structure and Cytotoxicity" International Journal of Molecular Sciences 22, no. 4: 1874. https://doi.org/10.3390/ijms22041874

APA Style

Ferraro, G., Pratesi, A., Cirri, D., Imbimbo, P., Maria Monti, D., Messori, L., & Merlino, A. (2021). Arsenoplatin-Ferritin Nanocage: Structure and Cytotoxicity. International Journal of Molecular Sciences, 22(4), 1874. https://doi.org/10.3390/ijms22041874

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