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Calprotectin in Lung Diseases

Department of Respiratory Medicine, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece
Department of Nursing, Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece
Human Nutrition, School of Medicine, College of Medical Veterinary and Life Sciences, University of Glasgow, Glasgow Royal Infirmary, Glasgow G31 2ER, UK
Author to whom correspondence should be addressed.
Academic Editor: William Cho
Int. J. Mol. Sci. 2021, 22(4), 1706;
Received: 24 December 2020 / Revised: 31 January 2021 / Accepted: 4 February 2021 / Published: 8 February 2021
(This article belongs to the Collection Precision Medicine—From Bench to Bedside)
Calprotectin (CLP) is a heterodimer formed by two S-100 calcium-binding cytosolic proteins, S100A8 and S100A9. It is a multifunctional protein expressed mainly by neutrophils and released extracellularly by activated or damaged cells mediating a broad range of physiological and pathological responses. It has been more than 20 years since the implication of S100A8/A9 in the inflammatory process was shown; however, the evaluation of its role in the pathogenesis of respiratory diseases or its usefulness as a biomarker for the appropriate diagnosis and prognosis of lung diseases have only gained attention in recent years. This review aimed to provide current knowledge regarding the potential role of CLP in the pathophysiology of lung diseases and describe how this knowledge is, up until now, translated into daily clinical practice. CLP is involved in numerous cellular processes in lung health and disease. In addition to its anti-microbial functions, CLP also serves as a molecule with pro- and anti-tumor properties related to cell survival and growth, angiogenesis, DNA damage response, and the remodeling of the extracellular matrix. The findings of this review potentially introduce CLP in daily clinical practice within the spectrum of respiratory diseases. View Full-Text
Keywords: biomarker; calgranulin; calprotectin; lung; S100A8/A9 biomarker; calgranulin; calprotectin; lung; S100A8/A9
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MDPI and ACS Style

Kotsiou, O.S.; Papagiannis, D.; Papadopoulou, R.; Gourgoulianis, K.I. Calprotectin in Lung Diseases. Int. J. Mol. Sci. 2021, 22, 1706.

AMA Style

Kotsiou OS, Papagiannis D, Papadopoulou R, Gourgoulianis KI. Calprotectin in Lung Diseases. International Journal of Molecular Sciences. 2021; 22(4):1706.

Chicago/Turabian Style

Kotsiou, Ourania S., Dimitrios Papagiannis, Rodanthi Papadopoulou, and Konstantinos I. Gourgoulianis 2021. "Calprotectin in Lung Diseases" International Journal of Molecular Sciences 22, no. 4: 1706.

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