Next Article in Journal
Differential Actions of Muscarinic Receptor Subtypes in Gastric, Pancreatic, and Colon Cancer
Next Article in Special Issue
Antibodies against Angiotensin II Type 1 and Endothelin 1 Type A Receptors in Cardiovascular Pathologies
Previous Article in Journal
Adsorption of 1,2-Dichlorobenzene from the Aqueous Phase onto Activated Carbons and Modified Carbon Nanotubes
Previous Article in Special Issue
Homocysteine Solution-Induced Response in Aerosol Jet Printed OECTs by Means of Gold and Platinum Gate Electrodes
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
IJMS
Volume 22
Issue 23
10.3390/ijms222313154
ijms-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors

by
Paola Cuomo
1,
Chiara Medaglia
2,
Ivana Allocca
1,
Angela Michela Immacolata Montone
3,
Fabrizia Guerra
4,
Serena Cabaro
5,
Ernesto Mollo
6,
Daniela Eletto
7,
Marina Papaianni
1 and
Rosanna Capparelli
8,*
1
Department of Agriculture, University of Naples Federico II, 80055 Naples, Italy
2
Department of Microbiology and Molecular Medicine, University of Geneva, Rue Michel-Servet 1, 1206 Geneva, Switzerland
3
Department of Food Inspection, Istituto Zooprofilattico Sperimentale del Mezzogiorno, 80055 Naples, Italy
4
Department of Pharmacy, University of Naples Federico II, 80131 Naples, Italy
5
Department of Translational Medicine, University of Naples Federico II, 80131 Naples, Italy
6
National Research Council of Italy, Institute of Biomolecular Chemistry, 80078 Naples, Italy
7
Department of Pharmacy, University of Salerno, Via Giovanni Paolo II 132, 84084 Salerno, Italy
8
Task Force Microbioma, Department of Agriculture, University of Naples Federico II, 80055 Naples, Italy
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(23), 13154; https://doi.org/10.3390/ijms222313154
Submission received: 20 October 2021 / Revised: 30 November 2021 / Accepted: 3 December 2021 / Published: 5 December 2021
(This article belongs to the Special Issue Old and New Players in Inflammatory Disorders—in Memory of Dr. Nadia Ferlazzo)
Browse Figures
Review Reports Versions Notes

Abstract

The identification of novel strategies to control Helicobacter pylori (Hp)-associated chronic inflammation is, at present, a considerable challenge. Here, we attempt to combat this issue by modulating the innate immune response, targeting formyl peptide receptors (FPRs), G-protein coupled receptors that play key roles in both the regulation and the resolution of the innate inflammatory response. Specifically, we investigated, in vitro, whether Caulerpin—a bis-indole alkaloid isolated from algae of the genus Caulerpa—could act as a molecular antagonist scaffold of FPRs. We showed that Caulerpin significantly reduces the immune response against Hp culture filtrate, by reverting the FPR2-related signaling cascade and thus counteracting the inflammatory reaction triggered by Hp peptide Hp(2–20). Our study suggests Caulerpin to be a promising therapeutic or adjuvant agent for the attenuation of inflammation triggered by Hp infection, as well as its related adverse clinical outcomes.
Keywords: Helicobacter pylori; formyl peptide receptors; inflammation; bis-indole structure Helicobacter pylori; formyl peptide receptors; inflammation; bis-indole structure

Share and Cite

MDPI and ACS Style

Cuomo, P.; Medaglia, C.; Allocca, I.; Montone, A.M.I.; Guerra, F.; Cabaro, S.; Mollo, E.; Eletto, D.; Papaianni, M.; Capparelli, R. Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors. Int. J. Mol. Sci. 2021, 22, 13154. https://doi.org/10.3390/ijms222313154

AMA Style

Cuomo P, Medaglia C, Allocca I, Montone AMI, Guerra F, Cabaro S, Mollo E, Eletto D, Papaianni M, Capparelli R. Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors. International Journal of Molecular Sciences. 2021; 22(23):13154. https://doi.org/10.3390/ijms222313154

Chicago/Turabian Style

Cuomo, Paola, Chiara Medaglia, Ivana Allocca, Angela Michela Immacolata Montone, Fabrizia Guerra, Serena Cabaro, Ernesto Mollo, Daniela Eletto, Marina Papaianni, and Rosanna Capparelli. 2021. "Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors" International Journal of Molecular Sciences 22, no. 23: 13154. https://doi.org/10.3390/ijms222313154

APA Style

Cuomo, P., Medaglia, C., Allocca, I., Montone, A. M. I., Guerra, F., Cabaro, S., Mollo, E., Eletto, D., Papaianni, M., & Capparelli, R. (2021). Caulerpin Mitigates Helicobacter pylori-Induced Inflammation via Formyl Peptide Receptors. International Journal of Molecular Sciences, 22(23), 13154. https://doi.org/10.3390/ijms222313154

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop