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Review

A Dynamic Network of Proteins Facilitate Cell Envelope Biogenesis in Gram-Negative Bacteria

1
School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK
2
School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK
*
Author to whom correspondence should be addressed.
Academic Editor: Paola Brun
Int. J. Mol. Sci. 2021, 22(23), 12831; https://doi.org/10.3390/ijms222312831
Received: 14 October 2021 / Revised: 2 November 2021 / Accepted: 3 November 2021 / Published: 27 November 2021
(This article belongs to the Special Issue Bacterial Cell Envelope Biosynthesis)
Bacteria must maintain the ability to modify and repair the peptidoglycan layer without jeopardising its essential functions in cell shape, cellular integrity and intermolecular interactions. A range of new experimental techniques is bringing an advanced understanding of how bacteria regulate and achieve peptidoglycan synthesis, particularly in respect of the central role played by complexes of Sporulation, Elongation or Division (SEDs) and class B penicillin-binding proteins required for cell division, growth and shape. In this review we highlight relationships implicated by a bioinformatic approach between the outer membrane, cytoskeletal components, periplasmic control proteins, and cell elongation/division proteins to provide further perspective on the interactions of these cell division, growth and shape complexes. We detail the network of protein interactions that assist in the formation of peptidoglycan and highlight the increasingly dynamic and connected set of protein machinery and macrostructures that assist in creating the cell envelope layers in Gram-negative bacteria. View Full-Text
Keywords: peptidoglycan; interactions; Escherichia coli; outer membrane; envelope; network; protein-protein; seds; complexes; dynamic; gram-negative; cell division; cytoskeleton peptidoglycan; interactions; Escherichia coli; outer membrane; envelope; network; protein-protein; seds; complexes; dynamic; gram-negative; cell division; cytoskeleton
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MDPI and ACS Style

Graham, C.L.B.; Newman, H.; Gillett, F.N.; Smart, K.; Briggs, N.; Banzhaf, M.; Roper, D.I. A Dynamic Network of Proteins Facilitate Cell Envelope Biogenesis in Gram-Negative Bacteria. Int. J. Mol. Sci. 2021, 22, 12831. https://doi.org/10.3390/ijms222312831

AMA Style

Graham CLB, Newman H, Gillett FN, Smart K, Briggs N, Banzhaf M, Roper DI. A Dynamic Network of Proteins Facilitate Cell Envelope Biogenesis in Gram-Negative Bacteria. International Journal of Molecular Sciences. 2021; 22(23):12831. https://doi.org/10.3390/ijms222312831

Chicago/Turabian Style

Graham, Chris L. B., Hector Newman, Francesca N. Gillett, Katie Smart, Nicholas Briggs, Manuel Banzhaf, and David I. Roper. 2021. "A Dynamic Network of Proteins Facilitate Cell Envelope Biogenesis in Gram-Negative Bacteria" International Journal of Molecular Sciences 22, no. 23: 12831. https://doi.org/10.3390/ijms222312831

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