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Review

The Role of the Immune System in IBD-Associated Colorectal Cancer: From Pro to Anti-Tumorigenic Mechanisms

1
Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Location AMC, 1105 AZ Amsterdam, The Netherlands
2
Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Centers, Location AMC, 1105 AZ Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Academic Editor: Massimo Triggiani
Int. J. Mol. Sci. 2021, 22(23), 12739; https://doi.org/10.3390/ijms222312739
Received: 7 October 2021 / Revised: 18 November 2021 / Accepted: 23 November 2021 / Published: 25 November 2021
Patients with inflammatory bowel disease (IBD) have increased incidence of colorectal cancer (CRC). IBD-associated cancer follows a well-characterized sequence of intestinal epithelial changes, in which genetic mutations and molecular aberrations play a key role. IBD-associated cancer develops against a background of chronic inflammation and pro-inflammatory immune cells, and their products contribute to cancer development and progression. In recent years, the effect of the immunosuppressive microenvironment in cancer development and progression has gained more attention, mainly because of the unprecedented anti-tumor effects of immune checkpoint inhibitors in selected groups of patients. Even though IBD-associated cancer develops in the background of chronic inflammation which is associated with activation of endogenous anti-inflammatory or suppressive mechanisms, the potential role of an immunosuppressive microenvironment in these cancers is largely unknown. In this review, we outline the role of the immune system in promoting cancer development in chronic inflammatory diseases such as IBD, with a specific focus on the anti-inflammatory mechanisms and suppressive immune cells that may play a role in IBD-associated tumorigenesis. View Full-Text
Keywords: IBD; IBD-associated cancer; inflammation; immune system; immune cells; immunosurveillance; immunosuppression; colitis-associated cancer; colorectal cancer IBD; IBD-associated cancer; inflammation; immune system; immune cells; immunosurveillance; immunosuppression; colitis-associated cancer; colorectal cancer
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MDPI and ACS Style

Frigerio, S.; Lartey, D.A.; D’Haens, G.R.; Grootjans, J. The Role of the Immune System in IBD-Associated Colorectal Cancer: From Pro to Anti-Tumorigenic Mechanisms. Int. J. Mol. Sci. 2021, 22, 12739. https://doi.org/10.3390/ijms222312739

AMA Style

Frigerio S, Lartey DA, D’Haens GR, Grootjans J. The Role of the Immune System in IBD-Associated Colorectal Cancer: From Pro to Anti-Tumorigenic Mechanisms. International Journal of Molecular Sciences. 2021; 22(23):12739. https://doi.org/10.3390/ijms222312739

Chicago/Turabian Style

Frigerio, Sofía, Dalia A. Lartey, Geert R. D’Haens, and Joep Grootjans. 2021. "The Role of the Immune System in IBD-Associated Colorectal Cancer: From Pro to Anti-Tumorigenic Mechanisms" International Journal of Molecular Sciences 22, no. 23: 12739. https://doi.org/10.3390/ijms222312739

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