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Histone Methylation Regulation in Neurodegenerative Disorders
Review

DNA Methylation in Huntington’s Disease

1
Department of Genetics, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, H-6726 Szeged, Hungary
2
Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of Szeged, Közép fasor 52, H-6726 Szeged, Hungary
3
Doctoral School in Biology, Faculty of Science and Informatics, University of Szeged, H-6726 Szeged, Hungary
*
Author to whom correspondence should be addressed.
Academic Editor: Cristoforo Comi
Int. J. Mol. Sci. 2021, 22(23), 12736; https://doi.org/10.3390/ijms222312736
Received: 3 November 2021 / Revised: 21 November 2021 / Accepted: 22 November 2021 / Published: 25 November 2021
(This article belongs to the Special Issue Epigenetic Regulation in Neurodegeneration Disease)
Methylation of cytosine in CpG dinucleotides is the major DNA modification in mammalian cells that is a key component of stable epigenetic marks. This modification, which on the one hand is reversible, while on the other hand, can be maintained through successive rounds of replication plays roles in gene regulation, genome maintenance, transgenerational epigenetic inheritance, and imprinting. Disturbed DNA methylation contributes to a wide array of human diseases from single-gene disorders to sporadic metabolic diseases or cancer. DNA methylation was also shown to affect several neurodegenerative disorders, including Huntington’s disease (HD), a fatal, monogenic inherited disease. HD is caused by a polyglutamine repeat expansion in the Huntingtin protein that brings about a multifaceted pathogenesis affecting several cellular processes. Research of the last decade found complex, genome-wide DNA methylation changes in HD pathogenesis that modulate transcriptional activity and genome stability. This article reviews current evidence that sheds light on the role of DNA methylation in HD. View Full-Text
Keywords: Huntington’s disease; neurodegeneration; DNA methylation; transcriptional dysregulation; CpG methylation; 5-methylcytosine; DNA methyltransferase Huntington’s disease; neurodegeneration; DNA methylation; transcriptional dysregulation; CpG methylation; 5-methylcytosine; DNA methyltransferase
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MDPI and ACS Style

Zsindely, N.; Siági, F.; Bodai, L. DNA Methylation in Huntington’s Disease. Int. J. Mol. Sci. 2021, 22, 12736. https://doi.org/10.3390/ijms222312736

AMA Style

Zsindely N, Siági F, Bodai L. DNA Methylation in Huntington’s Disease. International Journal of Molecular Sciences. 2021; 22(23):12736. https://doi.org/10.3390/ijms222312736

Chicago/Turabian Style

Zsindely, Nóra, Fruzsina Siági, and László Bodai. 2021. "DNA Methylation in Huntington’s Disease" International Journal of Molecular Sciences 22, no. 23: 12736. https://doi.org/10.3390/ijms222312736

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