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Drosophila Trachea as a Novel Model of COPD

Department of Biological Sciences, Oakland University, Rochester, MI 48309, USA
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Author to whom correspondence should be addressed.
Academic Editors: Athanassios D. Velentzas and Dimitrios J. Stravopodis
Int. J. Mol. Sci. 2021, 22(23), 12730; https://doi.org/10.3390/ijms222312730
Received: 29 October 2021 / Revised: 19 November 2021 / Accepted: 22 November 2021 / Published: 25 November 2021
COPD, a chronic obstructive pulmonary disease, is one of the leading causes of death worldwide. Clinical studies and research in rodent models demonstrated that failure of repair mechanisms to cope with increased ROS and inflammation in the lung leads to COPD. Despite this progress, the molecular mechanisms underlying the development of COPD remain poorly understood, resulting in a lack of effective treatments. Thus, an informative, simple model is highly valued and desired. Recently, the cigarette smoke-induced Drosophila COPD model showed a complex set of pathological phenotypes that resemble those seen in human COPD patients. The Drosophila trachea has been used as a premier model to reveal the mechanisms of tube morphogenesis. The association of these mechanisms to structural changes in COPD can be analyzed by using Drosophila trachea. Additionally, the timeline of structural damage, ROS, and inflammation can be studied in live organisms using fluorescently-tagged proteins. The related function of human COPD genes identified by GWAS can be screened using respective fly homologs. Finally, the Drosophila trachea can be used as a high-throughput drug screening platform to identify novel treatments for COPD. Therefore, Drosophila trachea is an excellent model that is complementary to rodent COPD models. View Full-Text
Keywords: COPD; Drosophila; trachea; model COPD; Drosophila; trachea; model
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MDPI and ACS Style

Scholl, A.; Ndoja, I.; Jiang, L. Drosophila Trachea as a Novel Model of COPD. Int. J. Mol. Sci. 2021, 22, 12730. https://doi.org/10.3390/ijms222312730

AMA Style

Scholl A, Ndoja I, Jiang L. Drosophila Trachea as a Novel Model of COPD. International Journal of Molecular Sciences. 2021; 22(23):12730. https://doi.org/10.3390/ijms222312730

Chicago/Turabian Style

Scholl, Aaron, Istri Ndoja, and Lan Jiang. 2021. "Drosophila Trachea as a Novel Model of COPD" International Journal of Molecular Sciences 22, no. 23: 12730. https://doi.org/10.3390/ijms222312730

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