Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review

Payet, Melissa; Dargai, Farouk; Gasque, Philippe; Guillot, Xavier

doi:10.3390/ijms222212170

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Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review

¹

Research Unit ‘Etudes en Pharmaco-Immunologie’ UR EPI, Université de la Réunion, 97400 Réunion, France

²

Orthopedic Clinical Department, CHU Bellepierre, Reunion University Hospital, 97400 Réunion, France

³

Immunology Laboratory (LICE-OI), CHU Bellepierre, Reunion University Hospital, 97400 Réunion, France

⁴

Rheumatology Clinical Department, CHU Bellepierre, Reunion University Hospital, 97400 Réunion, France

^*

Author to whom correspondence should be addressed.

Int. J. Mol. Sci. 2021, 22(22), 12170; https://doi.org/10.3390/ijms222212170

Submission received: 13 October 2021 / Revised: 3 November 2021 / Accepted: 6 November 2021 / Published: 10 November 2021

(This article belongs to the Special Issue Molecular Mechanisms of Rheumatoid Arthritis)

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Abstract

The inflammatory reaction in rheumatoid arthritis (RA) is controlled by major epigenetic modifications that modulate the phenotype of synovial and immune cells. The aim of this work was to perform a systematic review focusing on miR expression, DNA methylation and histone modifications in RA. We demonstrated that, in human samples, the expressions of miR-155, miR-146a and miR-150 were significantly decreased while the expression of miR-410-3p was significantly increased in the RA group. Moreover, miR-146a significantly decreased pro-autoimmune IL-17 cytokine expression in RA. In a murine model, miR-34a inhibition can ameliorate the arthritis score. However, this evidence remain critically insufficient to support current therapeutic applications in RA patients.

Keywords: rheumatoid arthritis epigenetic regulation; miR-155; miR-146a; miR-150; miR-410-3p; DNA methylation

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MDPI and ACS Style

Payet, M.; Dargai, F.; Gasque, P.; Guillot, X. Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review. Int. J. Mol. Sci. 2021, 22, 12170. https://doi.org/10.3390/ijms222212170

AMA Style

Payet M, Dargai F, Gasque P, Guillot X. Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review. International Journal of Molecular Sciences. 2021; 22(22):12170. https://doi.org/10.3390/ijms222212170

Chicago/Turabian Style

Payet, Melissa, Farouk Dargai, Philippe Gasque, and Xavier Guillot. 2021. "Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review" International Journal of Molecular Sciences 22, no. 22: 12170. https://doi.org/10.3390/ijms222212170

APA Style

Payet, M., Dargai, F., Gasque, P., & Guillot, X. (2021). Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review. International Journal of Molecular Sciences, 22(22), 12170. https://doi.org/10.3390/ijms222212170

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Epigenetic Regulation (Including Micro-RNAs, DNA Methylation and Histone Modifications) of Rheumatoid Arthritis: A Systematic Review

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