Tetraspanins: Host Factors in Viral Infections

New, ChihSheng; Lee, Zhao-Yong; Tan, Kai Sen; Wong, Amanda Huee-Ping; Wang, De Yun; Tran, Thai

doi:10.3390/ijms222111609

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Tetraspanins: Host Factors in Viral Infections

by

ChihSheng New

^1,2,†,

Zhao-Yong Lee

^1,2,†,

Kai Sen Tan

^1,3,4,5,

Amanda Huee-Ping Wong

^1,2,

De Yun Wang

^1,4,* and

Thai Tran

^1,2,*

¹

Infectious Disease Translational Research Program, National University of Singapore, Singapore 119228, Singapore

²

Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117593, Singapore

³

Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore

⁴

Department of Otolaryngology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore

⁵

Biosafety Level 3 Core Facility, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore 119228, Singapore

^*

Authors to whom correspondence should be addressed.

^†

Equal contribution.

Int. J. Mol. Sci. 2021, 22(21), 11609; https://doi.org/10.3390/ijms222111609

Submission received: 7 September 2021 / Revised: 22 October 2021 / Accepted: 23 October 2021 / Published: 27 October 2021

(This article belongs to the Special Issue Role of Signaling Pathways in the Viral Life Cycle 2.0)

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Abstract

Tetraspanins are transmembrane glycoproteins that have been shown increasing interest as host factors in infectious diseases. In particular, they were implicated in the pathogenesis of both non-enveloped (human papillomavirus (HPV)) and enveloped (human immunodeficiency virus (HIV), Zika, influenza A virus, (IAV), and coronavirus) viruses through multiple stages of infection, from the initial cell membrane attachment to the syncytium formation and viral particle release. However, the mechanisms by which different tetraspanins mediate their effects vary. This review aimed to compare and contrast the role of tetraspanins in the life cycles of HPV, HIV, Zika, IAV, and coronavirus viruses, which cause the most significant health and economic burdens to society. In doing so, a better understanding of the relative contribution of tetraspanins in virus infection will allow for a more targeted approach in the treatment of these diseases.

Keywords: CD9; CD63; CD151; CD81; coronavirus; COVID-19; HIV; HPV; influenza; tetraspanin; virus; Zika

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MDPI and ACS Style

New, C.; Lee, Z.-Y.; Tan, K.S.; Wong, A.H.-P.; Wang, D.Y.; Tran, T. Tetraspanins: Host Factors in Viral Infections. Int. J. Mol. Sci. 2021, 22, 11609. https://doi.org/10.3390/ijms222111609

AMA Style

New C, Lee Z-Y, Tan KS, Wong AH-P, Wang DY, Tran T. Tetraspanins: Host Factors in Viral Infections. International Journal of Molecular Sciences. 2021; 22(21):11609. https://doi.org/10.3390/ijms222111609

Chicago/Turabian Style

New, ChihSheng, Zhao-Yong Lee, Kai Sen Tan, Amanda Huee-Ping Wong, De Yun Wang, and Thai Tran. 2021. "Tetraspanins: Host Factors in Viral Infections" International Journal of Molecular Sciences 22, no. 21: 11609. https://doi.org/10.3390/ijms222111609

APA Style

New, C., Lee, Z.-Y., Tan, K. S., Wong, A. H.-P., Wang, D. Y., & Tran, T. (2021). Tetraspanins: Host Factors in Viral Infections. International Journal of Molecular Sciences, 22(21), 11609. https://doi.org/10.3390/ijms222111609

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

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