Next Article in Journal
FluCell-SELEX Aptamers as Specific Binding Molecules for Diagnostics of the Health Relevant Gut Bacterium Akkermansia muciniphila
Next Article in Special Issue
Type 1 Diabetes Mellitus and the First Trimester Placenta: Hyperglycemia-Induced Effects on Trophoblast Proliferation, Cell Cycle Regulators, and Invasion
Previous Article in Journal
Synthesis of Oxidized 3β,3′β-Disteryl Ethers and Search after High-Temperature Treatment of Sterol-Rich Samples
Previous Article in Special Issue
Placental Complement Activation in Fetal and Neonatal Alloimmune Thrombocytopenia: An Observational Study
Article

Maternal C-Peptide and Insulin Sensitivity, but Not BMI, Associate with Fatty Acids in the First Trimester of Pregnancy

1
Department of Obstetrics and Gynaecology, Medical University of Graz, 8036 Graz, Austria
2
Faculty of Pharmacy, Universidad San Pablo CEU, 28668 Madrid, Spain
3
Femina Med-Center, 8010 Graz, Austria
4
Institute of Human Movement Science, Sport and Health, University of Graz, 8010 Graz, Austria
*
Authors to whom correspondence should be addressed.
Academic Editor: Marie-Pierre Piccinni
Int. J. Mol. Sci. 2021, 22(19), 10422; https://doi.org/10.3390/ijms221910422
Received: 17 August 2021 / Revised: 19 September 2021 / Accepted: 24 September 2021 / Published: 27 September 2021
(This article belongs to the Special Issue Molecular Aspects of Inflammation in Pregnancy 2.0)
Maternal obesity in pregnancy is a pro-inflammatory condition exposing the fetus to an adverse environment. Here, we tested associations of maternal obesity (primary exposures: BMI, leptin) and metabolic parameters (secondary exposures: glucose, C-peptide, and insulin sensitivity) with total serum concentrations of fatty acids in the first trimester of human pregnancy. This cross-sectional study included 123 non-smoking women with singleton pregnancy. In maternal serum, cotinine, leptin, and C-peptide (ELISA), glucose (hexokinase-based test) and fatty acids (gas chromatography) were quantified, and the insulin sensitivity index (ISHOMA) was calculated. Concentrations of fatty acid classes and total fatty acids did not differ between BMI or leptin categories. However, n-3 polyunsaturated fatty acids (PUFA) were decreased in the category with the highest C-peptide concentration (n-3 PUFA: CI −35.82–−6.28, p < 0.006) and in the lowest ISHOMA category (n-3 PUFA: CI −36.48–−5.61, p < 0.008). In a subcohort, in which fetal sex was determined (RT-qPCR of placental tissue), C-peptide was significantly associated with docosahexaenoic acid (DHA) in mothers bearing a female (n = 46), but not male (n = 37) fetus. In conclusion, pregnant women with high fasting C-peptide and low ISHOMA had decreased n-3 PUFA, and DHA was lower with higher C-peptide only in mothers bearing a female fetus. View Full-Text
Keywords: early pregnancy; obesity; fatty acids; glucose; C-peptide; insulin sensitivity; fetal sex early pregnancy; obesity; fatty acids; glucose; C-peptide; insulin sensitivity; fetal sex
Show Figures

Figure 1

MDPI and ACS Style

Bandres-Meriz, J.; Majali-Martinez, A.; Hoch, D.; Morante, M.; Glasner, A.; van Poppel, M.N.M.; Desoye, G.; Herrera, E. Maternal C-Peptide and Insulin Sensitivity, but Not BMI, Associate with Fatty Acids in the First Trimester of Pregnancy. Int. J. Mol. Sci. 2021, 22, 10422. https://doi.org/10.3390/ijms221910422

AMA Style

Bandres-Meriz J, Majali-Martinez A, Hoch D, Morante M, Glasner A, van Poppel MNM, Desoye G, Herrera E. Maternal C-Peptide and Insulin Sensitivity, but Not BMI, Associate with Fatty Acids in the First Trimester of Pregnancy. International Journal of Molecular Sciences. 2021; 22(19):10422. https://doi.org/10.3390/ijms221910422

Chicago/Turabian Style

Bandres-Meriz, Julia, Alejandro Majali-Martinez, Denise Hoch, Milagros Morante, Andreas Glasner, Mireille N.M. van Poppel, Gernot Desoye, and Emilio Herrera. 2021. "Maternal C-Peptide and Insulin Sensitivity, but Not BMI, Associate with Fatty Acids in the First Trimester of Pregnancy" International Journal of Molecular Sciences 22, no. 19: 10422. https://doi.org/10.3390/ijms221910422

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop