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Review

Presence, Mode of Action, and Application of Pathway Specific Transcription Factors in Aspergillus Biosynthetic Gene Clusters

1
Ocean College, Zhejiang University, Zhoushan 316021, China
2
Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA
3
Department of Bacteriology, University of Wisconsin-Madison, Madison, WI 53706, USA
*
Authors to whom correspondence should be addressed.
Academic Editor: Gabriel Santpere
Int. J. Mol. Sci. 2021, 22(16), 8709; https://doi.org/10.3390/ijms22168709
Received: 28 July 2021 / Revised: 10 August 2021 / Accepted: 10 August 2021 / Published: 13 August 2021
Fungal secondary metabolites are renowned toxins as well as valuable sources of antibiotics, cholesterol-lowering drugs, and immunosuppressants; hence, great efforts were levied to understand how these compounds are genetically regulated. The genes encoding for the enzymes required for synthesizing secondary metabolites are arranged in biosynthetic gene clusters (BGCs). Often, BGCs contain a pathway specific transcription factor (PSTF), a valuable tool in shutting down or turning up production of the BGC product. In this review, we present an in-depth view of PSTFs by examining over 40 characterized BGCs in the well-studied fungal species Aspergillus nidulans and Aspergillus fumigatus. Herein, we find BGC size is a predictor for presence of PSTFs, consider the number and the relative location of PSTF in regard to the cluster(s) regulated, discuss the function and the evolution of PSTFs, and present application strategies for pathway specific activation of cryptic BGCs. View Full-Text
Keywords: pathway specific transcription factor; transcription factor; Aspergillus; regulation; evolution pathway specific transcription factor; transcription factor; Aspergillus; regulation; evolution
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MDPI and ACS Style

Wang, W.; Yu, Y.; Keller, N.P.; Wang, P. Presence, Mode of Action, and Application of Pathway Specific Transcription Factors in Aspergillus Biosynthetic Gene Clusters. Int. J. Mol. Sci. 2021, 22, 8709. https://doi.org/10.3390/ijms22168709

AMA Style

Wang W, Yu Y, Keller NP, Wang P. Presence, Mode of Action, and Application of Pathway Specific Transcription Factors in Aspergillus Biosynthetic Gene Clusters. International Journal of Molecular Sciences. 2021; 22(16):8709. https://doi.org/10.3390/ijms22168709

Chicago/Turabian Style

Wang, Wenjie, Yuchao Yu, Nancy P. Keller, and Pinmei Wang. 2021. "Presence, Mode of Action, and Application of Pathway Specific Transcription Factors in Aspergillus Biosynthetic Gene Clusters" International Journal of Molecular Sciences 22, no. 16: 8709. https://doi.org/10.3390/ijms22168709

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