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Human Mitochondrial RNA Processing and Modifications: Overview

Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5A, 02-106 Warsaw, Poland
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Author to whom correspondence should be addressed.
Academic Editor: Carlo Vascotto
Int. J. Mol. Sci. 2021, 22(15), 7999; https://doi.org/10.3390/ijms22157999
Received: 18 June 2021 / Revised: 23 July 2021 / Accepted: 24 July 2021 / Published: 27 July 2021
(This article belongs to the Special Issue Mitochondrial DNA and RNA)
Mitochondria, often referred to as the powerhouses of cells, are vital organelles that are present in almost all eukaryotic organisms, including humans. They are the key energy suppliers as the site of adenosine triphosphate production, and are involved in apoptosis, calcium homeostasis, and regulation of the innate immune response. Abnormalities occurring in mitochondria, such as mitochondrial DNA (mtDNA) mutations and disturbances at any stage of mitochondrial RNA (mtRNA) processing and translation, usually lead to severe mitochondrial diseases. A fundamental line of investigation is to understand the processes that occur in these organelles and their physiological consequences. Despite substantial progress that has been made in the field of mtRNA processing and its regulation, many unknowns and controversies remain. The present review discusses the current state of knowledge of RNA processing in human mitochondria and sheds some light on the unresolved issues. View Full-Text
Keywords: mitochondria; mitochondrial transcription; RNA processing; RNA decay; RNA modifications; mitochondrial genome mitochondria; mitochondrial transcription; RNA processing; RNA decay; RNA modifications; mitochondrial genome
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MDPI and ACS Style

Jedynak-Slyvka, M.; Jabczynska, A.; Szczesny, R.J. Human Mitochondrial RNA Processing and Modifications: Overview. Int. J. Mol. Sci. 2021, 22, 7999. https://doi.org/10.3390/ijms22157999

AMA Style

Jedynak-Slyvka M, Jabczynska A, Szczesny RJ. Human Mitochondrial RNA Processing and Modifications: Overview. International Journal of Molecular Sciences. 2021; 22(15):7999. https://doi.org/10.3390/ijms22157999

Chicago/Turabian Style

Jedynak-Slyvka, Marta, Agata Jabczynska, and Roman J. Szczesny 2021. "Human Mitochondrial RNA Processing and Modifications: Overview" International Journal of Molecular Sciences 22, no. 15: 7999. https://doi.org/10.3390/ijms22157999

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