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Six Decades of Research on Human Fetal Gonadal Steroids

Univ Rennes, Inserm, EHESP, Irset (Institut de Recherche en Santé, Environnement et Travail), UMR_S 1085, 35000 Rennes, France
Fougères Laboratory, French Agency for Food, Environmental and Occupational Health & Safety (ANSES), CEDEX, 35306 Fougères, France
Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
Author to whom correspondence should be addressed.
Academic Editors: Cathy Vaillancourt, Thierry Charlier and Devaleena S. Pradhan
Int. J. Mol. Sci. 2021, 22(13), 6681;
Received: 12 April 2021 / Revised: 14 June 2021 / Accepted: 18 June 2021 / Published: 22 June 2021
Human fetal gonads acquire endocrine steroidogenic capabilities early during their differentiation. Genetic studies show that this endocrine function plays a central role in the sexually dimorphic development of the external genitalia during fetal development. When this endocrine function is dysregulated, congenital malformations and pathologies are the result. In this review, we explain how the current knowledge of steroidogenesis in human fetal gonads has benefited from both the technological advances in steroid measurements and the assembly of detailed knowledge of steroidogenesis machinery and its expression in human fetal gonads. We summarise how the conversion of radiolabelled steroid precursors, antibody-based assays, mass spectrometry, ultrastructural studies, and the in situ labelling of proteins and mRNA have all provided complementary information. In this review, our discussion goes beyond the debate on recommendations concerning the best choice between the different available technologies, and their degrees of reproducibility and sensitivity. The available technologies and techniques can be used for different purposes and, as long as all quality controls are rigorously employed, the question is how to maximise the generation of robust, reproducible data on steroid hormones and their crucial roles in human fetal development and subsequent functions. View Full-Text
Keywords: detection; quantification; testis; ovary; steroidogenesis; androgens; estrogens; human; fetal detection; quantification; testis; ovary; steroidogenesis; androgens; estrogens; human; fetal
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MDPI and ACS Style

Connan-Perrot, S.; Léger, T.; Lelandais, P.; Desdoits-Lethimonier, C.; David, A.; Fowler, P.A.; Mazaud-Guittot, S. Six Decades of Research on Human Fetal Gonadal Steroids. Int. J. Mol. Sci. 2021, 22, 6681.

AMA Style

Connan-Perrot S, Léger T, Lelandais P, Desdoits-Lethimonier C, David A, Fowler PA, Mazaud-Guittot S. Six Decades of Research on Human Fetal Gonadal Steroids. International Journal of Molecular Sciences. 2021; 22(13):6681.

Chicago/Turabian Style

Connan-Perrot, Stéphane, Thibaut Léger, Pauline Lelandais, Christèle Desdoits-Lethimonier, Arthur David, Paul A. Fowler, and Séverine Mazaud-Guittot. 2021. "Six Decades of Research on Human Fetal Gonadal Steroids" International Journal of Molecular Sciences 22, no. 13: 6681.

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