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Article

Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice

by
Macarena González-Portilla
1,
Sandra Montagud-Romero
2,
Francisco Navarrete
3,4,
Ani Gasparyan
3,4,
Jorge Manzanares
3,4,
José Miñarro
1,4 and
Marta Rodríguez-Arias
1,4,*
1
Department of Psychobiology, Facultad de Psicología, Universitat de Valencia, Avda. Blasco Ibáñez 21, 46010 Valencia, Spain
2
Department of Psychology and Sociology, University of Zaragoza, C/ Ciudad Escolar s/n, 44003 Teruel, Spain
3
Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, Avda. de Ramón y Cajal s/n, San Juan de Alicante, 03550 Alicante, Spain
4
Red Temática de Investigación Cooperativa en Salud (RETICS-Trastornos Adictivos), Instituto de Salud Carlos III, MICINN and FEDER, 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(10), 5279; https://doi.org/10.3390/ijms22105279
Submission received: 9 April 2021 / Revised: 8 May 2021 / Accepted: 15 May 2021 / Published: 17 May 2021
(This article belongs to the Special Issue Gut Microbiota and Immunity)
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Abstract

Alcohol binge drinking (BD) and poor nutritional habits are two frequent behaviors among many adolescents that alter gut microbiota in a pro-inflammatory direction. Dysbiotic changes in the gut microbiome are observed after alcohol and high-fat diet (HFD) consumption, even before obesity onset. In this study, we investigate the neuroinflammatory response of adolescent BD when combined with a continuous or intermittent HFD and its effects on adult ethanol consumption by using a self-administration (SA) paradigm in mice. The inflammatory biomarkers IL-6 and CX3CL1 were measured in the striatum 24 h after BD, 3 weeks later and after the ethanol (EtOH) SA. Adolescent BD increased alcohol consumption in the oral SA and caused a greater motivation to seek the substance. Likewise, mice with intermittent access to HFD exhibited higher EtOH consumption, while the opposite effect was found in mice with continuous HFD access. Biochemical analyses showed that after BD and three weeks later, striatal levels of IL-6 and CX3CL1 were increased. In addition, in saline-treated mice, CX3CL1 was increased after continuous access to HFD. After oral SA procedure, striatal IL-6 was increased only in animals exposed to BD and HFD. In addition, striatal CX3CL1 levels were increased in all BD- and HFD-exposed groups. Overall, our findings show that adolescent BD and intermittent HFD increase adult alcohol intake and point to neuroinflammation as an important mechanism modulating this interaction.
Keywords: binge drinking; alcohol; high-fat diet; binge; microbiota; cytokines; inflammation binge drinking; alcohol; high-fat diet; binge; microbiota; cytokines; inflammation

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MDPI and ACS Style

González-Portilla, M.; Montagud-Romero, S.; Navarrete, F.; Gasparyan, A.; Manzanares, J.; Miñarro, J.; Rodríguez-Arias, M. Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice. Int. J. Mol. Sci. 2021, 22, 5279. https://doi.org/10.3390/ijms22105279

AMA Style

González-Portilla M, Montagud-Romero S, Navarrete F, Gasparyan A, Manzanares J, Miñarro J, Rodríguez-Arias M. Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice. International Journal of Molecular Sciences. 2021; 22(10):5279. https://doi.org/10.3390/ijms22105279

Chicago/Turabian Style

González-Portilla, Macarena, Sandra Montagud-Romero, Francisco Navarrete, Ani Gasparyan, Jorge Manzanares, José Miñarro, and Marta Rodríguez-Arias. 2021. "Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice" International Journal of Molecular Sciences 22, no. 10: 5279. https://doi.org/10.3390/ijms22105279

APA Style

González-Portilla, M., Montagud-Romero, S., Navarrete, F., Gasparyan, A., Manzanares, J., Miñarro, J., & Rodríguez-Arias, M. (2021). Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice. International Journal of Molecular Sciences, 22(10), 5279. https://doi.org/10.3390/ijms22105279

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