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Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment

1
National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health, Bethesda, MD 20892, USA
2
Department of Immunology and Microbiology, School of Medicine, University of Texas Rio Grande Valley, McAllen, TX 78504, USA
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Mohd W. Nasser
Int. J. Mol. Sci. 2021, 22(10), 5278; https://doi.org/10.3390/ijms22105278
Received: 19 April 2021 / Revised: 5 May 2021 / Accepted: 11 May 2021 / Published: 17 May 2021
(This article belongs to the Special Issue Cytokines/Chemokines in Cancer Metastasis 2.0)
Exosomes are nanoscale vesicles generated by cells for intercellular communication. Due to their composition, significant research has been conducted to transform these particles into specific delivery systems for various disease states. In this review, we discuss the common isolation and loading methods of exosomes, some of the major roles of exosomes in the tumor microenvironment, as well as discuss recent applications of exosomes as drug delivery vessels and the resulting clinical implications. View Full-Text
Keywords: exosome; tumor microenvironment; miRNAs; lncRNAs exosome; tumor microenvironment; miRNAs; lncRNAs
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MDPI and ACS Style

Massey, A.E.; Malik, S.; Sikander, M.; Doxtater, K.A.; Tripathi, M.K.; Khan, S.; Yallapu, M.M.; Jaggi, M.; Chauhan, S.C.; Hafeez, B.B. Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment. Int. J. Mol. Sci. 2021, 22, 5278. https://doi.org/10.3390/ijms22105278

AMA Style

Massey AE, Malik S, Sikander M, Doxtater KA, Tripathi MK, Khan S, Yallapu MM, Jaggi M, Chauhan SC, Hafeez BB. Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment. International Journal of Molecular Sciences. 2021; 22(10):5278. https://doi.org/10.3390/ijms22105278

Chicago/Turabian Style

Massey, Andrew E., Shabnam Malik, Mohammad Sikander, Kyle A. Doxtater, Manish K. Tripathi, Sheema Khan, Murali M. Yallapu, Meena Jaggi, Subhash C. Chauhan, and Bilal B. Hafeez 2021. "Clinical Implications of Exosomes: Targeted Drug Delivery for Cancer Treatment" International Journal of Molecular Sciences 22, no. 10: 5278. https://doi.org/10.3390/ijms22105278

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