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Microglia–Neuron Crosstalk in Obesity: Melodious Interaction or Kiss of Death?

Neurocentre Magendie, Physiopathologie de la Plasticité Neuronale, INSERM U1215, University of Bordeaux, 33000 Bordeaux, France
Author to whom correspondence should be addressed.
Academic Editors: Rosalía Rodríguez-Rodríguez and Cristina Miralpeix
Int. J. Mol. Sci. 2021, 22(10), 5243;
Received: 22 April 2021 / Revised: 11 May 2021 / Accepted: 13 May 2021 / Published: 15 May 2021
(This article belongs to the Special Issue Hypothalamic Regulation of Obesity)
Diet-induced obesity can originate from the dysregulated activity of hypothalamic neuronal circuits, which are critical for the regulation of body weight and food intake. The exact mechanisms underlying such neuronal defects are not yet fully understood, but a maladaptive cross-talk between neurons and surrounding microglial is likely to be a contributing factor. Functional and anatomical connections between microglia and hypothalamic neuronal cells are at the core of how the brain orchestrates changes in the body’s metabolic needs. However, such a melodious interaction may become maladaptive in response to prolonged diet-induced metabolic stress, thereby causing overfeeding, body weight gain, and systemic metabolic perturbations. From this perspective, we critically discuss emerging molecular and cellular underpinnings of microglia–neuron communication in the hypothalamic neuronal circuits implicated in energy balance regulation. We explore whether changes in this intercellular dialogue induced by metabolic stress may serve as a protective neuronal mechanism or contribute to disease establishment and progression. Our analysis provides a framework for future mechanistic studies that will facilitate progress into both the etiology and treatments of metabolic disorders. View Full-Text
Keywords: microglia–neuron communication; hypothalamus; obesity; metabolism microglia–neuron communication; hypothalamus; obesity; metabolism
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MDPI and ACS Style

Léon, S.; Nadjar, A.; Quarta, C. Microglia–Neuron Crosstalk in Obesity: Melodious Interaction or Kiss of Death? Int. J. Mol. Sci. 2021, 22, 5243.

AMA Style

Léon S, Nadjar A, Quarta C. Microglia–Neuron Crosstalk in Obesity: Melodious Interaction or Kiss of Death? International Journal of Molecular Sciences. 2021; 22(10):5243.

Chicago/Turabian Style

Léon, Stéphane, Agnès Nadjar, and Carmelo Quarta. 2021. "Microglia–Neuron Crosstalk in Obesity: Melodious Interaction or Kiss of Death?" International Journal of Molecular Sciences 22, no. 10: 5243.

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