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Volume 22
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Article

Effect of Ecdysterone on the Hepatic Transcriptome and Lipid Metabolism in Lean and Obese Zucker Rats

by
Magdalena J. M. Marschall
1,
Robert Ringseis
1,*,
Denise K. Gessner
1,
Sarah M. Grundmann
1,
Erika Most
1,
Gaiping Wen
1,
Garima Maheshwari
1,2,
Holger Zorn
2,3 and
Klaus Eder
1
1
Institute of Animal Nutrition and Nutrition Physiology, Justus-Liebig-University Giessen, Heinrich-Buff-Ring 26-32, 35392 Giessen, Germany
2
Institute of Food Chemistry and Food Biotechnology, Justus-Liebig-University Giessen, Heinrich-Buff-Ring 17, 35392 Giessen, Germany
3
Fraunhofer Institute for Molecular Biology and Applied Ecology, Ohlebergsweg 12, 35392 Giessen, Germany
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2021, 22(10), 5241; https://doi.org/10.3390/ijms22105241
Submission received: 15 March 2021 / Revised: 11 May 2021 / Accepted: 13 May 2021 / Published: 15 May 2021
(This article belongs to the Special Issue Insects and Their Derived Products—an Innovative Source of Bioactives and Nutraceuticals)
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Abstract

Conflicting reports exist with regard to the effect of ecdysterone, the predominating representative of steroid hormones in insects and plants, on hepatic and plasma lipid concentrations in different rodent models of obesity, fatty liver, and diabetes, indicating that the effect is dependent on the rodent model used. Here, the hypothesis was tested for the first time that ecdysterone causes lipid-lowering effects in genetically obese Zucker rats. To test this hypothesis, two groups of male obese Zucker rats (n = 8) were fed a nutrient-adequate diet supplemented without or with 0.5 g ecdysterone per kg diet. To study further if ecdysterone is capable of alleviating the strong lipid-synthetic activity in the liver of obese Zucker rats, the study included also two groups of male lean Zucker rats (n = 8) which also received either the ecdysterone-supplemented or the non-supplemented diet. While hepatic and plasma concentrations of triglycerides and cholesterol were markedly higher in the obese compared to the lean rats (p < 0.05), hepatic and plasma triglyceride and cholesterol concentrations did not differ between rats of the same genotype fed the diets without or with ecdysterone. In conclusion, the present study clearly shows that ecdysterone supplementation does not exhibit lipid-lowering actions in the liver and plasma of lean and obese Zucker rats.
Keywords: ecdysterone; 20-hydroxyecdysone; lipid metabolism; liver; triglyceride; cholesterol; obese Zucker rat; obesity; transcriptome ecdysterone; 20-hydroxyecdysone; lipid metabolism; liver; triglyceride; cholesterol; obese Zucker rat; obesity; transcriptome

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MDPI and ACS Style

Marschall, M.J.M.; Ringseis, R.; Gessner, D.K.; Grundmann, S.M.; Most, E.; Wen, G.; Maheshwari, G.; Zorn, H.; Eder, K. Effect of Ecdysterone on the Hepatic Transcriptome and Lipid Metabolism in Lean and Obese Zucker Rats. Int. J. Mol. Sci. 2021, 22, 5241. https://doi.org/10.3390/ijms22105241

AMA Style

Marschall MJM, Ringseis R, Gessner DK, Grundmann SM, Most E, Wen G, Maheshwari G, Zorn H, Eder K. Effect of Ecdysterone on the Hepatic Transcriptome and Lipid Metabolism in Lean and Obese Zucker Rats. International Journal of Molecular Sciences. 2021; 22(10):5241. https://doi.org/10.3390/ijms22105241

Chicago/Turabian Style

Marschall, Magdalena J. M., Robert Ringseis, Denise K. Gessner, Sarah M. Grundmann, Erika Most, Gaiping Wen, Garima Maheshwari, Holger Zorn, and Klaus Eder. 2021. "Effect of Ecdysterone on the Hepatic Transcriptome and Lipid Metabolism in Lean and Obese Zucker Rats" International Journal of Molecular Sciences 22, no. 10: 5241. https://doi.org/10.3390/ijms22105241

APA Style

Marschall, M. J. M., Ringseis, R., Gessner, D. K., Grundmann, S. M., Most, E., Wen, G., Maheshwari, G., Zorn, H., & Eder, K. (2021). Effect of Ecdysterone on the Hepatic Transcriptome and Lipid Metabolism in Lean and Obese Zucker Rats. International Journal of Molecular Sciences, 22(10), 5241. https://doi.org/10.3390/ijms22105241

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