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Review

Ubiquitin-Mediated Control of ETS Transcription Factors: Roles in Cancer and Development

Queen’s Medical Centre, School of Life Sciences, University of Nottingham, Nottingham NG7 2UH, UK
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Academic Editor: Kwang-Hyun Baek
Int. J. Mol. Sci. 2021, 22(10), 5119; https://doi.org/10.3390/ijms22105119
Received: 30 March 2021 / Revised: 6 May 2021 / Accepted: 7 May 2021 / Published: 12 May 2021
Genome expansion, whole genome and gene duplication events during metazoan evolution produced an extensive family of ETS genes whose members express transcription factors with a conserved winged helix-turn-helix DNA-binding domain. Unravelling their biological roles has proved challenging with functional redundancy manifest in overlapping expression patterns, a common consensus DNA-binding motif and responsiveness to mitogen-activated protein kinase signalling. Key determinants of the cellular repertoire of ETS proteins are their stability and turnover, controlled largely by the actions of selective E3 ubiquitin ligases and deubiquitinases. Here we discuss the known relationships between ETS proteins and enzymes that determine their ubiquitin status, their integration with other developmental signal transduction pathways and how suppression of ETS protein ubiquitination contributes to the malignant cell phenotype in multiple cancers. View Full-Text
Keywords: E3 ligase complex; deubiquitinase; gene fusions; mitogens; phosphorylation; DNA damage E3 ligase complex; deubiquitinase; gene fusions; mitogens; phosphorylation; DNA damage
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MDPI and ACS Style

Ducker, C.; Shaw, P.E. Ubiquitin-Mediated Control of ETS Transcription Factors: Roles in Cancer and Development. Int. J. Mol. Sci. 2021, 22, 5119. https://doi.org/10.3390/ijms22105119

AMA Style

Ducker C, Shaw PE. Ubiquitin-Mediated Control of ETS Transcription Factors: Roles in Cancer and Development. International Journal of Molecular Sciences. 2021; 22(10):5119. https://doi.org/10.3390/ijms22105119

Chicago/Turabian Style

Ducker, Charles, and Peter E. Shaw 2021. "Ubiquitin-Mediated Control of ETS Transcription Factors: Roles in Cancer and Development" International Journal of Molecular Sciences 22, no. 10: 5119. https://doi.org/10.3390/ijms22105119

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