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Article

Bacopa monnieri (L.) Wettst. Extract Improves Memory Performance via Promotion of Neurogenesis in the Hippocampal Dentate Gyrus of Adolescent Mice

1
Department of Pharmacology and Biochemistry, National Institute of Medicinal Materials, Hoan Kiem District, Hanoi 100000, Vietnam
2
National Geriatric Hospital, Dong Da District, Hanoi 100000, Vietnam
3
Faculty of Pharmaceutical Sciences, Setsunan University, Osaka 573-0101, Japan
4
Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
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Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Sakyo-ku, Kyoto 603-8585, Japan
6
Department of Kampo Pharmacology, Daiichi University of Pharmacy, Fukuoka 815-8511, Japan
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(9), 3365; https://doi.org/10.3390/ijms21093365
Received: 20 April 2020 / Revised: 5 May 2020 / Accepted: 7 May 2020 / Published: 9 May 2020
(This article belongs to the Special Issue Mechanism of Adult Neurogenesis)
Bacopa monnieri L. Wettst. (BM) is a botanical component of Ayurvedic medicines and of dietary supplements used worldwide for cognitive health and function. We previously reported that administration of BM alcoholic extract (BME) prevents trimethyltin (TMT)-induced cognitive deficits and hippocampal cell damage and promotes TMT-induced hippocampal neurogenesis. In this study, we demonstrate that administration of BME improves spatial working memory in adolescent (5-week- old) healthy mice but not adult (8-week-old) mice. Moreover, improved spatial working memory was retained even at 4 weeks after terminating 1-week treatment of adolescent mice. One-week BME treatment of adolescent mice significantly enhanced hippocampal BrdU incorporation and expression of genes involved in neurogenesis determined by RNAseq analysis. Cell death, as detected by histochemistry, appeared not to be significant. A significant increase in neurogenesis was observed in the dentate gyrus region 4 weeks after terminating 1-week treatment of adolescent mice with BME. Bacopaside I, an active component of BME, promoted the proliferation of neural progenitor cells in vitro in a concentration-dependent manner via the facilitation of the Akt and ERK1/2 signaling. These results suggest that BME enhances spatial working memory in healthy adolescent mice by promoting hippocampal neurogenesis and that the effects of BME are due, in significant amounts, to bacopaside I. View Full-Text
Keywords: Bacopa monnieri; cognitive improvement; neurogenesis; neural stem/progenitor cell; dentate gyrus; RNAseq Bacopa monnieri; cognitive improvement; neurogenesis; neural stem/progenitor cell; dentate gyrus; RNAseq
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MDPI and ACS Style

Pham, H.T.N.; Tran, H.N.; Nguyen, P.T.; Le, X.T.; Nguyen, K.M.; Phan, S.V.; Yoneyama, M.; Ogita, K.; Yamaguchi, T.; Folk, W.R.; Yamaguchi, M.; Matsumoto, K. Bacopa monnieri (L.) Wettst. Extract Improves Memory Performance via Promotion of Neurogenesis in the Hippocampal Dentate Gyrus of Adolescent Mice. Int. J. Mol. Sci. 2020, 21, 3365. https://doi.org/10.3390/ijms21093365

AMA Style

Pham HTN, Tran HN, Nguyen PT, Le XT, Nguyen KM, Phan SV, Yoneyama M, Ogita K, Yamaguchi T, Folk WR, Yamaguchi M, Matsumoto K. Bacopa monnieri (L.) Wettst. Extract Improves Memory Performance via Promotion of Neurogenesis in the Hippocampal Dentate Gyrus of Adolescent Mice. International Journal of Molecular Sciences. 2020; 21(9):3365. https://doi.org/10.3390/ijms21093365

Chicago/Turabian Style

Pham, Hang Thi Nguyet, Hong Nguyen Tran, Phuong Thi Nguyen, Xoan Thi Le, Khoi Minh Nguyen, Sinh Viet Phan, Masanori Yoneyama, Kiyokazu Ogita, Taro Yamaguchi, William R. Folk, Masamitsu Yamaguchi, and Kinzo Matsumoto. 2020. "Bacopa monnieri (L.) Wettst. Extract Improves Memory Performance via Promotion of Neurogenesis in the Hippocampal Dentate Gyrus of Adolescent Mice" International Journal of Molecular Sciences 21, no. 9: 3365. https://doi.org/10.3390/ijms21093365

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