Rubrofusarin Attenuates Chronic Restraint Stress-Induced Depressive Symptoms
Abstract
:1. Introduction
2. Results
2.1. Chronic Rubrofusarin Administration Ameliorated Chronic Restraint Stress (CRS)-Induced Depressive Symptoms
2.2. Chronic Rubrofusarin Administration Rescued CRS-Induced Hippocampal Neuronal Damage
2.3. Chronic Rubrofusarin Administration Blocked CRS-Induced Reduction of Adult Neurogenesis
2.4. Chronic Rubrofusarin Administration Blocked CRS-Induced Neuroinflammation
2.5. Chronic Rubrofusarin Administration Blocked CRS-Induced Synaptic Dysfunctions
2.6. Rubrofusarin Blocked Corticosterone-Induced LTP Impairment Through Regulating the Akt Signaling
2.7. Akt Signaling Was Required for the Antidepressive Effect of Rubrofusarin
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Restraint Stress
4.3. Objective Recognition Memory Test
4.4. Forced Swimming Test
4.5. Tissue Slices Preparation
4.6. Floro-Jade B Staining
4.7. Immunohistochemistry
4.8. Hippocampal Slices Preparation and Electrophysiology
4.9. Microinfusion of Drugs
4.10. Statistics
Author Contributions
Funding
Conflicts of Interest
Abbreviations
CRS | Chronic restraint stress |
REDD1 | Regulated in development and DNA damage responses 1 |
NLRP3 | Nod-like receptor family pyrin domain containing 3 |
GSK-3 | Glycogen synthase kinase-3 |
PI3K | Phosphoinositide 3-kinases |
ACSF | Artificial cerebrospinal fluid |
fEPSP | Field excitatory postsynaptic potential |
TBS | Theta burst stimulation |
LTP | Long-term potentiation |
RF | Rubrofusarin |
FLX | Fluoxetine |
DG | Dentate gyrus |
CORT | Corticosterone |
NMDAR | N-methyl-d-aspartate receptor |
GR | Glucocorticoid receptor |
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Yi, J.H.; Jeon, J.; Kwon, H.; Cho, E.; Yun, J.; Lee, Y.C.; Ryu, J.H.; Park, S.J.; Cho, J.H.; Kim, D.H. Rubrofusarin Attenuates Chronic Restraint Stress-Induced Depressive Symptoms. Int. J. Mol. Sci. 2020, 21, 3454. https://doi.org/10.3390/ijms21103454
Yi JH, Jeon J, Kwon H, Cho E, Yun J, Lee YC, Ryu JH, Park SJ, Cho JH, Kim DH. Rubrofusarin Attenuates Chronic Restraint Stress-Induced Depressive Symptoms. International Journal of Molecular Sciences. 2020; 21(10):3454. https://doi.org/10.3390/ijms21103454
Chicago/Turabian StyleYi, Jee Hyun, Jieun Jeon, Huiyoung Kwon, Eunbi Cho, Jeanho Yun, Young Choon Lee, Jong Hoon Ryu, Se Jin Park, Jong Hyun Cho, and Dong Hyun Kim. 2020. "Rubrofusarin Attenuates Chronic Restraint Stress-Induced Depressive Symptoms" International Journal of Molecular Sciences 21, no. 10: 3454. https://doi.org/10.3390/ijms21103454