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Project Report

The EDCMET Project: Metabolic Effects of Endocrine Disruptors

1
A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, FI-70210 Kuopio, Finland
2
School of Pharmacy, University of Eastern Finland, P.O. Box 1627, FI-70210 Kuopio, Finland
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Institute of Biomedicine, University of Eastern Finland, P.O. Box 1627, FI-70210 Kuopio, Finland
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Department Food Safety, German Federal Institute for Risk Assessment, DE-10589 Berlin, Germany
5
Arctic Health, Faculty of Medicine, University of Oulu, P.O. Box 5000, FI-90014 Oulu, Finland
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Thule Institute, University of Arctic, University of Oulu, P.O. Box 8000, FI-90014 Oulu, Finland
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Research Unit of Biomedicine, Pharmacology and Toxicology, University of Oulu, P.O. Box 5000, FI-90014 Oulu, Finland
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Department of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(8), 3021; https://doi.org/10.3390/ijms21083021
Received: 30 March 2020 / Revised: 21 April 2020 / Accepted: 22 April 2020 / Published: 24 April 2020
(This article belongs to the Special Issue Advances in the Research of Endocrine Disrupting Chemicals 2.0)
Endocrine disruptors (EDs) are defined as chemicals that mimic, block, or interfere with hormones in the body’s endocrine systems and have been associated with a diverse array of health issues. The concept of endocrine disruption has recently been extended to metabolic alterations that may result in diseases, such as obesity, diabetes, and fatty liver disease, and constitute an increasing health concern worldwide. However, while epidemiological and experimental data on the close association of EDs and adverse metabolic effects are mounting, predictive methods and models to evaluate the detailed mechanisms and pathways behind these observed effects are lacking, thus restricting the regulatory risk assessment of EDs. The EDCMET (Metabolic effects of Endocrine Disrupting Chemicals: novel testing METhods and adverse outcome pathways) project brings together systems toxicologists; experimental biologists with a thorough understanding of the molecular mechanisms of metabolic disease and comprehensive in vitro and in vivo methodological skills; and, ultimately, epidemiologists linking environmental exposure to adverse metabolic outcomes. During its 5-year journey, EDCMET aims to identify novel ED mechanisms of action, to generate (pre)validated test methods to assess the metabolic effects of Eds, and to predict emergent adverse biological phenotypes by following the adverse outcome pathway (AOP) paradigm. View Full-Text
Keywords: endocrine disruptors (EDs); nuclear receptors (NRs); metabolism; metabolic syndrome; obesity; risk assessment; human health; adverse outcome pathway (AOP); assay validation endocrine disruptors (EDs); nuclear receptors (NRs); metabolism; metabolic syndrome; obesity; risk assessment; human health; adverse outcome pathway (AOP); assay validation
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MDPI and ACS Style

Küblbeck, J.; Vuorio, T.; Niskanen, J.; Fortino, V.; Braeuning, A.; Abass, K.; Rautio, A.; Hakkola, J.; Honkakoski, P.; Levonen, A.-L. The EDCMET Project: Metabolic Effects of Endocrine Disruptors. Int. J. Mol. Sci. 2020, 21, 3021. https://doi.org/10.3390/ijms21083021

AMA Style

Küblbeck J, Vuorio T, Niskanen J, Fortino V, Braeuning A, Abass K, Rautio A, Hakkola J, Honkakoski P, Levonen A-L. The EDCMET Project: Metabolic Effects of Endocrine Disruptors. International Journal of Molecular Sciences. 2020; 21(8):3021. https://doi.org/10.3390/ijms21083021

Chicago/Turabian Style

Küblbeck, Jenni; Vuorio, Taina; Niskanen, Jonna; Fortino, Vittorio; Braeuning, Albert; Abass, Khaled; Rautio, Arja; Hakkola, Jukka; Honkakoski, Paavo; Levonen, Anna-Liisa. 2020. "The EDCMET Project: Metabolic Effects of Endocrine Disruptors" Int. J. Mol. Sci. 21, no. 8: 3021. https://doi.org/10.3390/ijms21083021

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