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Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals—The ATHENA Project

1
Institute of Environment, Health and Societies, Brunel University London, Uxbridge UB8 3PH, UK
2
National Food Institute, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark
3
School of Science and Technology, Orebro University, SE-701 82 Orebro, Sweden
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Department of Health Sciences, Karlstad University, SE-651 88 Karlstad, Sweden
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Department of Environment and Health, Vrije Universiteit Amsterdam, VUA, 1081 HV Amsterdam, The Netherlands
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Unité PhyMA Laboratory, Adaptation du Vivant, Muséum national d’Histoire naturelle, Centre National de la Recherche Scientifique CNRS 7, rue Cuvier, F-75005 Paris, France
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Department of Internal Medicine, Academic Center for Thyroid Diseases, Erasmus Medical Centre, 3000 CA Rotterdam, The Netherlands
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Department of Experimental Endocrinology, Charitė - Universitätsmedizin Berlin, D-13353 Berlin, Germany
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Dept. of Experimental Neurology, Dept. of Neurology, Center for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, D-10117 Berlin, Germany
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Charité-BIH Centrum Therapy and Research, BIH Stem Cell Core Facility, Charité – Universitätsmedizin Berlin, D-13353 Berlin, Germany
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Department of C4hemical Process and Pharmaceutical Development, Research Institutes Sweden, RISE, SE-151 36 Sodertalje, Sweden
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Berlin Institute of Health, D-10178 Berlin, Germany
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Laboratoire Watchfrog, F-91000 Evry, France
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(9), 3123; https://doi.org/10.3390/ijms21093123
Received: 31 March 2020 / Revised: 20 April 2020 / Accepted: 24 April 2020 / Published: 28 April 2020
(This article belongs to the Special Issue Advances in the Research of Endocrine Disrupting Chemicals 2.0)
The test methods that currently exist for the identification of thyroid hormone system-disrupting chemicals are woefully inadequate. There are currently no internationally validated in vitro assays, and test methods that can capture the consequences of diminished or enhanced thyroid hormone action on the developing brain are missing entirely. These gaps put the public at risk and risk assessors in a difficult position. Decisions about the status of chemicals as thyroid hormone system disruptors currently are based on inadequate toxicity data. The ATHENA project (Assays for the identification of Thyroid Hormone axis-disrupting chemicals: Elaborating Novel Assessment strategies) has been conceived to address these gaps. The project will develop new test methods for the disruption of thyroid hormone transport across biological barriers such as the blood–brain and blood–placenta barriers. It will also devise methods for the disruption of the downstream effects on the brain. ATHENA will deliver a testing strategy based on those elements of the thyroid hormone system that, when disrupted, could have the greatest impact on diminished or enhanced thyroid hormone action and therefore should be targeted through effective testing. To further enhance the impact of the ATHENA test method developments, the project will develop concepts for better international collaboration and development in the area of thyroid hormone system disruptor identification and regulation. View Full-Text
Keywords: endocrine disruptors; thyroid hormone system; brain development; test method development; test method validation; risk assessment endocrine disruptors; thyroid hormone system; brain development; test method development; test method validation; risk assessment
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MDPI and ACS Style

Kortenkamp, A.; Axelstad, M.; Baig, A.H.; Bergman, Å.; Bornehag, C.-G.; Cenijn, P.; Christiansen, S.; Demeneix, B.; Derakhshan, A.; Fini, J.-B.; Frädrich, C.; Hamers, T.; Hellwig, L.; Köhrle, J.; Korevaar, T.I.M.; Lindberg, J.; Martin, O.; Meima, M.E.; Mergenthaler, P.; Nikolov, N.; Du Pasquier, D.; Peeters, R.P.; Platzack, B.; Ramhøj, L.; Remaud, S.; Renko, K.; Scholze, M.; Stachelscheid, H.; Svingen, T.; Wagenaars, F.; Wedebye, E.B.; Zoeller, R.T. Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals—The ATHENA Project. Int. J. Mol. Sci. 2020, 21, 3123. https://doi.org/10.3390/ijms21093123

AMA Style

Kortenkamp A, Axelstad M, Baig AH, Bergman Å, Bornehag C-G, Cenijn P, Christiansen S, Demeneix B, Derakhshan A, Fini J-B, Frädrich C, Hamers T, Hellwig L, Köhrle J, Korevaar TIM, Lindberg J, Martin O, Meima ME, Mergenthaler P, Nikolov N, Du Pasquier D, Peeters RP, Platzack B, Ramhøj L, Remaud S, Renko K, Scholze M, Stachelscheid H, Svingen T, Wagenaars F, Wedebye EB, Zoeller RT. Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals—The ATHENA Project. International Journal of Molecular Sciences. 2020; 21(9):3123. https://doi.org/10.3390/ijms21093123

Chicago/Turabian Style

Kortenkamp, Andreas; Axelstad, Marta; Baig, Asma H.; Bergman, Åke; Bornehag, Carl-Gustaf; Cenijn, Peter; Christiansen, Sofie; Demeneix, Barbara; Derakhshan, Arash; Fini, Jean-Baptiste; Frädrich, Caroline; Hamers, Timo; Hellwig, Lina; Köhrle, Josef; Korevaar, Tim I.M.; Lindberg, Johan; Martin, Olwenn; Meima, Marcel E.; Mergenthaler, Philipp; Nikolov, Nikolai; Du Pasquier, David; Peeters, Robin P.; Platzack, Bjorn; Ramhøj, Louise; Remaud, Sylvie; Renko, Kostja; Scholze, Martin; Stachelscheid, Harald; Svingen, Terje; Wagenaars, Fabian; Wedebye, Eva B.; Zoeller, R. T. 2020. "Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals—The ATHENA Project" Int. J. Mol. Sci. 21, no. 9: 3123. https://doi.org/10.3390/ijms21093123

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