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Open AccessArticle

Ileal Transcriptome Profiles of Japanese Quail Divergent in Phosphorus Utilization

Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany
Institute of Animal Science, University of Hohenheim, 70599 Stuttgart, Germany
Faculty of Agricultural and Environmental Sciences, University Rostock, 18059 Rostock, Germany
Author to whom correspondence should be addressed.
Authors contributed equally to the work.
Int. J. Mol. Sci. 2020, 21(8), 2762;
Received: 19 January 2020 / Revised: 14 April 2020 / Accepted: 14 April 2020 / Published: 16 April 2020
(This article belongs to the Special Issue Exploring the Genotype–Phenotype Map: Regulatory Pathways)
Phosphorus (P) is an essential component for all living beings. Low P diets prompt phenotypic and molecular adaptations to maintain P homeostasis and increase P utilization (PU). Knowledge of the molecular mechanisms of PU is needed to enable targeted approaches to improve PU efficiency and thus lower P excretion in animal husbandry. In a previous population study, Japanese quail were subjected to a low P diet lacking mineral P and exogenous phytase. Individual PU was determined based on total P intake and excretion. A subset of 20 extreme siblings discordant for PU was selected to retrieve gene expression patterns of ileum (n = 10 per PU group). Sequencing reads have been successfully mapped to the current Coturnix japonica reference genome with an average mapping rate of 86%. In total, 640 genes were found to be differentially abundant between the low and high PU groups (false discovery rate ≤ 0.05). Transcriptional patterns suggest a link between improved PU and mitochondrial energy metabolism, accelerated cell proliferation of enterocytes, and gut integrity. In assessing indicators of the efficient use of macro- and micronutrients, further research on turnover and proliferation rates of intestinal cells could provide an approach to improve P efficiency in poultry species. View Full-Text
Keywords: phosphorus use; intestinal expression profiles; fowl; quail physiology phosphorus use; intestinal expression profiles; fowl; quail physiology
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Oster, M.; Reyer, H.; Trakooljul, N.; Weber, F.M.; Xi, L.; Muráni, E.; Ponsuksili, S.; Rodehutscord, M.; Bennewitz, J.; Wimmers, K. Ileal Transcriptome Profiles of Japanese Quail Divergent in Phosphorus Utilization. Int. J. Mol. Sci. 2020, 21, 2762.

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