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Open AccessArticle

Ileal Transcriptome Profiles of Japanese Quail Divergent in Phosphorus Utilization

1
Leibniz Institute for Farm Animal Biology (FBN), 18196 Dummerstorf, Germany
2
Institute of Animal Science, University of Hohenheim, 70599 Stuttgart, Germany
3
Faculty of Agricultural and Environmental Sciences, University Rostock, 18059 Rostock, Germany
*
Author to whom correspondence should be addressed.
Authors contributed equally to the work.
Int. J. Mol. Sci. 2020, 21(8), 2762; https://doi.org/10.3390/ijms21082762
Received: 19 January 2020 / Revised: 14 April 2020 / Accepted: 14 April 2020 / Published: 16 April 2020
(This article belongs to the Special Issue Exploring the Genotype–Phenotype Map: Regulatory Pathways)
Phosphorus (P) is an essential component for all living beings. Low P diets prompt phenotypic and molecular adaptations to maintain P homeostasis and increase P utilization (PU). Knowledge of the molecular mechanisms of PU is needed to enable targeted approaches to improve PU efficiency and thus lower P excretion in animal husbandry. In a previous population study, Japanese quail were subjected to a low P diet lacking mineral P and exogenous phytase. Individual PU was determined based on total P intake and excretion. A subset of 20 extreme siblings discordant for PU was selected to retrieve gene expression patterns of ileum (n = 10 per PU group). Sequencing reads have been successfully mapped to the current Coturnix japonica reference genome with an average mapping rate of 86%. In total, 640 genes were found to be differentially abundant between the low and high PU groups (false discovery rate ≤ 0.05). Transcriptional patterns suggest a link between improved PU and mitochondrial energy metabolism, accelerated cell proliferation of enterocytes, and gut integrity. In assessing indicators of the efficient use of macro- and micronutrients, further research on turnover and proliferation rates of intestinal cells could provide an approach to improve P efficiency in poultry species. View Full-Text
Keywords: phosphorus use; intestinal expression profiles; fowl; quail physiology phosphorus use; intestinal expression profiles; fowl; quail physiology
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Oster, M.; Reyer, H.; Trakooljul, N.; Weber, F.M.; Xi, L.; Muráni, E.; Ponsuksili, S.; Rodehutscord, M.; Bennewitz, J.; Wimmers, K. Ileal Transcriptome Profiles of Japanese Quail Divergent in Phosphorus Utilization. Int. J. Mol. Sci. 2020, 21, 2762.

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