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Review

Serotonin in Animal Cognition and Behavior

1
INCIA, UMR5287, Centre National de la Recherche Scientifique, 33076 Bordeaux, France
2
Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, 09100 Cagliari, Italy
3
Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, Malta
4
School of Biosciences, Neuroscience Division, Cardiff University, Cardiff CF24 4HQ, UK
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(5), 1649; https://doi.org/10.3390/ijms21051649
Received: 30 January 2020 / Revised: 25 February 2020 / Accepted: 25 February 2020 / Published: 28 February 2020
(This article belongs to the Special Issue Serotonin in Health and Disease)
Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of nervous systems in both invertebrates and vertebrates. It has been proposed for several decades that it impacts animal cognition and behavior. In spite of a completely distinct organization of the 5-HT systems across the animal kingdom, several lines of evidence suggest that the influences of 5-HT on behavior and cognition are evolutionary conserved. In this review, we have selected some behaviors classically evoked when addressing the roles of 5-HT on nervous system functions. In particular, we focus on the motor activity, arousal, sleep and circadian rhythm, feeding, social interactions and aggressiveness, anxiety, mood, learning and memory, or impulsive/compulsive dimension and behavioral flexibility. The roles of 5-HT, illustrated in both invertebrates and vertebrates, show that it is more able to potentiate or mitigate the neuronal responses necessary for the fine-tuning of most behaviors, rather than to trigger or halt a specific behavior. 5-HT is, therefore, the prototypical neuromodulator fundamentally involved in the adaptation of all organisms across the animal kingdom. View Full-Text
Keywords: serotonin receptor; animal phyla; mood; decision-making; locomotion; anxiety; neuronal excitability; feeding; aggressiveness; impulsive/compulsive dimension serotonin receptor; animal phyla; mood; decision-making; locomotion; anxiety; neuronal excitability; feeding; aggressiveness; impulsive/compulsive dimension
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MDPI and ACS Style

Bacqué-Cazenave, J.; Bharatiya, R.; Barrière, G.; Delbecque, J.-P.; Bouguiyoud, N.; Di Giovanni, G.; Cattaert, D.; De Deurwaerdère, P. Serotonin in Animal Cognition and Behavior. Int. J. Mol. Sci. 2020, 21, 1649. https://doi.org/10.3390/ijms21051649

AMA Style

Bacqué-Cazenave J, Bharatiya R, Barrière G, Delbecque J-P, Bouguiyoud N, Di Giovanni G, Cattaert D, De Deurwaerdère P. Serotonin in Animal Cognition and Behavior. International Journal of Molecular Sciences. 2020; 21(5):1649. https://doi.org/10.3390/ijms21051649

Chicago/Turabian Style

Bacqué-Cazenave, Julien, Rahul Bharatiya, Grégory Barrière, Jean-Paul Delbecque, Nouhaila Bouguiyoud, Giuseppe Di Giovanni, Daniel Cattaert, and Philippe De Deurwaerdère. 2020. "Serotonin in Animal Cognition and Behavior" International Journal of Molecular Sciences 21, no. 5: 1649. https://doi.org/10.3390/ijms21051649

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