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Serotonin in Animal Cognition and Behavior

INCIA, UMR5287, Centre National de la Recherche Scientifique, 33076 Bordeaux, France
Department of Biomedical Sciences, Section of Neuroscience and Clinical Pharmacology, University of Cagliari, 09100 Cagliari, Italy
Laboratory of Neurophysiology, Department of Physiology and Biochemistry, Faculty of Medicine and Surgery, University of Malta, MSD 2080 Msida, Malta
School of Biosciences, Neuroscience Division, Cardiff University, Cardiff CF24 4HQ, UK
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(5), 1649;
Received: 30 January 2020 / Revised: 25 February 2020 / Accepted: 25 February 2020 / Published: 28 February 2020
(This article belongs to the Special Issue Serotonin in Health and Disease)
Serotonin (5-hydroxytryptamine, 5-HT) is acknowledged as a major neuromodulator of nervous systems in both invertebrates and vertebrates. It has been proposed for several decades that it impacts animal cognition and behavior. In spite of a completely distinct organization of the 5-HT systems across the animal kingdom, several lines of evidence suggest that the influences of 5-HT on behavior and cognition are evolutionary conserved. In this review, we have selected some behaviors classically evoked when addressing the roles of 5-HT on nervous system functions. In particular, we focus on the motor activity, arousal, sleep and circadian rhythm, feeding, social interactions and aggressiveness, anxiety, mood, learning and memory, or impulsive/compulsive dimension and behavioral flexibility. The roles of 5-HT, illustrated in both invertebrates and vertebrates, show that it is more able to potentiate or mitigate the neuronal responses necessary for the fine-tuning of most behaviors, rather than to trigger or halt a specific behavior. 5-HT is, therefore, the prototypical neuromodulator fundamentally involved in the adaptation of all organisms across the animal kingdom. View Full-Text
Keywords: serotonin receptor; animal phyla; mood; decision-making; locomotion; anxiety; neuronal excitability; feeding; aggressiveness; impulsive/compulsive dimension serotonin receptor; animal phyla; mood; decision-making; locomotion; anxiety; neuronal excitability; feeding; aggressiveness; impulsive/compulsive dimension
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MDPI and ACS Style

Bacqué-Cazenave, J.; Bharatiya, R.; Barrière, G.; Delbecque, J.-P.; Bouguiyoud, N.; Di Giovanni, G.; Cattaert, D.; De Deurwaerdère, P. Serotonin in Animal Cognition and Behavior. Int. J. Mol. Sci. 2020, 21, 1649.

AMA Style

Bacqué-Cazenave J, Bharatiya R, Barrière G, Delbecque J-P, Bouguiyoud N, Di Giovanni G, Cattaert D, De Deurwaerdère P. Serotonin in Animal Cognition and Behavior. International Journal of Molecular Sciences. 2020; 21(5):1649.

Chicago/Turabian Style

Bacqué-Cazenave, Julien, Rahul Bharatiya, Grégory Barrière, Jean-Paul Delbecque, Nouhaila Bouguiyoud, Giuseppe Di Giovanni, Daniel Cattaert, and Philippe De Deurwaerdère. 2020. "Serotonin in Animal Cognition and Behavior" International Journal of Molecular Sciences 21, no. 5: 1649.

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