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Article

Acute and Chronic Nicotine Exposures Differentially Affect Central Serotonin 2A Receptor Function: Focus on the Lateral Habenula

1
Dipartimento di Scienze Mediche Veterinarie, Università di Bologna, Bologna, Via Tolara di Sopra, 50, 40064 Ozzano dell’Emilia (BO), Italy
2
Department of Physiology and Biochemistry, Laboratory of Neurophysiology, Faculty of Medicine and Surgery, University of Malta, MSD2080 Msida, Malta
3
Department of Biomedicine, Neuroscience and Advances Diagnosis (BIND), Human Physiology Section “Giuseppe Pagano”, Laboratory of Behavioral Physiology, University of Palermo, Viale delle Scienze n. 13, 90128 Palermo, Italy
4
Centre National de la Recherche Scientifique (Unité Mixte de Recherche 5287), 146 rue Léo Saignat, B.P.281, F-33000 Bordeaux Cedex, France
5
School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(5), 1873; https://doi.org/10.3390/ijms21051873
Received: 3 February 2020 / Accepted: 6 March 2020 / Published: 9 March 2020
(This article belongs to the Special Issue Serotonin in Health and Disease)
Nicotine addiction is a serious public health problem causing millions of deaths worldwide. Serotonin (5-hydroxytryptamine; 5-HT) is involved in central nervous system (CNS) nicotine effects, and it has been suggested as a promising pharmacological target for smoking cessation. In this regard, what is particularly interesting are the 5-HT2A receptors (5-HT2ARs) and the lateral habenula (LHb), a central area in nicotine addiction that we showed to be under a strong 5-HT2AR-modulation. Single-cell extracellular recording of LHb neurons was used to study the 5-HT2AR function by intravenously administrating the potent agonist TCB-2. Acute nicotine (2 mg/kg, intraperitoneal, i.p.) and chronic nicotine (6 mg/kg/day for 14 days) differently affected both the 5-HT2AR-immuno reactive (IR) neuron number and the 5-HT2AR immunostaining area in the different brain areas studied. After acute nicotine, TCB-2 cumulative doses (5–640 µg/kg, intravenous, i.v.) bidirectionally affected the activity of 74% of LHb recorded neurons. After chronic nicotine treatment, TCB-2 was only capable of decreasing the LHb firing rate. The expression of 5-HT2AR under acute and chronic nicotine exposure was studied in the LHb and in other brain areas involved in nicotine effects in rats by using immunohistochemistry. These data reveal that acute and chronic nicotine differentially affect the 5-HT2AR function in different brain areas and this might be relevant in nicotine addiction and its treatment. View Full-Text
Keywords: 5-HT2CR; nucleus accumbens; dorsal raphe nucleus; addiction; depression; medial prefrontal cortex; dentate gyrus; striatum; ventral tegmental area; substantia nigra pars compacta 5-HT2CR; nucleus accumbens; dorsal raphe nucleus; addiction; depression; medial prefrontal cortex; dentate gyrus; striatum; ventral tegmental area; substantia nigra pars compacta
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MDPI and ACS Style

Bombardi, C.; Delicata, F.; Tagliavia, C.; Pierucci, M.; Deidda, G.; Casarrubea, M.; De Deurwaerdère, P.; Di Giovanni, G. Acute and Chronic Nicotine Exposures Differentially Affect Central Serotonin 2A Receptor Function: Focus on the Lateral Habenula. Int. J. Mol. Sci. 2020, 21, 1873. https://doi.org/10.3390/ijms21051873

AMA Style

Bombardi C, Delicata F, Tagliavia C, Pierucci M, Deidda G, Casarrubea M, De Deurwaerdère P, Di Giovanni G. Acute and Chronic Nicotine Exposures Differentially Affect Central Serotonin 2A Receptor Function: Focus on the Lateral Habenula. International Journal of Molecular Sciences. 2020; 21(5):1873. https://doi.org/10.3390/ijms21051873

Chicago/Turabian Style

Bombardi, Cristiano, Francis Delicata, Claudio Tagliavia, Massimo Pierucci, Gabriele Deidda, Maurizio Casarrubea, Philippe De Deurwaerdère, and Giuseppe Di Giovanni. 2020. "Acute and Chronic Nicotine Exposures Differentially Affect Central Serotonin 2A Receptor Function: Focus on the Lateral Habenula" International Journal of Molecular Sciences 21, no. 5: 1873. https://doi.org/10.3390/ijms21051873

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