Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies

Conte, Elena; Bresciani, Elena; Rizzi, Laura; Cappellari, Ornella; De Luca, Annamaria; Torsello, Antonio; Liantonio, Antonella

doi:10.3390/ijms21041242

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Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies

by

Elena Conte

^1,†,

Elena Bresciani

^2,†

,

Laura Rizzi

²

,

Ornella Cappellari

¹

,

Annamaria De Luca

¹,

Antonio Torsello

² and

Antonella Liantonio

^1,*

¹

Department of Pharmacy-Drug Sciences, University of Bari, 70125 Bari, Italy

²

School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy

^*

Author to whom correspondence should be addressed.

^†

These authors equally contributed to the work.

Int. J. Mol. Sci. 2020, 21(4), 1242; https://doi.org/10.3390/ijms21041242

Submission received: 14 January 2020 / Revised: 8 February 2020 / Accepted: 9 February 2020 / Published: 13 February 2020

(This article belongs to the Special Issue Cisplatin in Cancer Therapy: Molecular Mechanisms of Action)

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Abstract

Among the severe side effects induced by cisplatin chemotherapy, muscle wasting is the most relevant one. This effect is a major cause for a clinical decline of cancer patients, since it is a negative predictor of treatment outcome and associated to increased mortality. However, despite its toxicity even at low doses, cisplatin remains the first-line therapy for several types of solid tumors. Thus, effective pharmacological treatments counteracting or minimizing cisplatin-induced muscle wasting are urgently needed. The dissection of the molecular pathways responsible for cisplatin-induced muscle dysfunction gives the possibility to identify novel promising therapeutic targets. In this context, the use of animal model of cisplatin-induced cachexia is very useful. Here, we report an update of the most relevant researches on the mechanisms underlying cisplatin-induced muscle wasting and on the most promising potential therapeutic options to preserve muscle mass and function.

Keywords: cisplatin; skeletal muscle; ghrelin; growth hormone secretagogues (GHS); muscle atrophy

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MDPI and ACS Style

Conte, E.; Bresciani, E.; Rizzi, L.; Cappellari, O.; De Luca, A.; Torsello, A.; Liantonio, A. Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies. Int. J. Mol. Sci. 2020, 21, 1242. https://doi.org/10.3390/ijms21041242

AMA Style

Conte E, Bresciani E, Rizzi L, Cappellari O, De Luca A, Torsello A, Liantonio A. Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies. International Journal of Molecular Sciences. 2020; 21(4):1242. https://doi.org/10.3390/ijms21041242

Chicago/Turabian Style

Conte, Elena, Elena Bresciani, Laura Rizzi, Ornella Cappellari, Annamaria De Luca, Antonio Torsello, and Antonella Liantonio. 2020. "Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies" International Journal of Molecular Sciences 21, no. 4: 1242. https://doi.org/10.3390/ijms21041242

APA Style

Conte, E., Bresciani, E., Rizzi, L., Cappellari, O., De Luca, A., Torsello, A., & Liantonio, A. (2020). Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies. International Journal of Molecular Sciences, 21(4), 1242. https://doi.org/10.3390/ijms21041242

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Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies

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