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Targeting MAPK Signaling in Cancer: Mechanisms of Drug Resistance and Sensitivity
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Mitogen-Activated Protein Kinase (MAPK) and Obesity-Related Cancer

Ireland East Hospital Gynaeoncology Group, UCD School of Medicine, Mater Misericordiae University, D07R2WY Dublin 7, Ireland
Queensland Centre for Gynaecological Cancer Research, The University of Queensland, Brisbane QLD 4029, Australia
Systems Biology Ireland, UCD School of Medicine, Belfield, D04V1W8 Dublin 4, Ireland
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(4), 1241;
Received: 31 December 2019 / Revised: 6 February 2020 / Accepted: 12 February 2020 / Published: 13 February 2020
(This article belongs to the Special Issue Targeting MAPK in Cancer)
Obesity is a major public health concern worldwide. The increased risk of certain types of cancer is now an established deleterious consequence of obesity, although the molecular mechanisms of this are not completely understood. In this review, we aim to explore the links between MAPK signalling and obesity-related cancer. We focus mostly on p38 and JNK MAPK, as the role of ERK remains unclear. These links are seen through the implication of MAPK in obesity-related immune paralysis as well as through effects on the endoplasmic reticulum stress response and activation of aromatase. By way of example, we highlight areas of interest and possibilities for future research in endometrioid endometrial cancer and hepatocellular carcinoma associated with non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and MAPK. View Full-Text
Keywords: obesity; MAPK; cancer; endometrial cancer; hepatocellular cancer obesity; MAPK; cancer; endometrial cancer; hepatocellular cancer
MDPI and ACS Style

Donohoe, F.; Wilkinson, M.; Baxter, E.; Brennan, D.J. Mitogen-Activated Protein Kinase (MAPK) and Obesity-Related Cancer. Int. J. Mol. Sci. 2020, 21, 1241.

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