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Killer Immunoglobulin-Like Receptor 2DL4 (CD158d) Regulates Human Mast Cells both Positively and Negatively: Possible Roles in Pregnancy and Cancer Metastasis

Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto 606-8507, Japan
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Int. J. Mol. Sci. 2020, 21(3), 954; https://doi.org/10.3390/ijms21030954
Received: 25 December 2019 / Revised: 29 January 2020 / Accepted: 30 January 2020 / Published: 31 January 2020
(This article belongs to the Special Issue Activation and Modulation of Mast Cells)
Killer immunoglobulin-like receptor (KIR) 2DL4 (CD158d) was previously thought to be a human NK cell-specific protein. Mast cells are involved in allergic reactions via their KIT-mediated and FcɛRI-mediated responses. We recently detected the expression of KIR2DL4 in human cultured mast cells established from peripheral blood of healthy volunteers (PB-mast), in the human mast cell line LAD2, and in human tissue mast cells. Agonistic antibodies against KIR2DL4 negatively regulate the KIT-mediated and FcɛRI-mediated responses of PB-mast and LAD2 cells. In addition, agonistic antibodies and human leukocyte antigen (HLA)-G, a natural ligand for KIR2DL4, induce the secretion of leukemia inhibitory factor and serine proteases from human mast cells, which have been implicated in pregnancy establishment and cancer metastasis. Therefore, KIR2DL4 stimulation with agonistic antibodies and recombinant HLA-G protein may enhance both processes, in addition to suppressing mast-cell-mediated allergic reactions. View Full-Text
Keywords: allergic reaction; CD158d; FcɛRI; KIR2DL4; KIT; mast cell; pregnancy allergic reaction; CD158d; FcɛRI; KIR2DL4; KIT; mast cell; pregnancy
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MDPI and ACS Style

Kataoka, T.R.; Ueshima, C.; Hirata, M.; Minamiguchi, S.; Haga, H. Killer Immunoglobulin-Like Receptor 2DL4 (CD158d) Regulates Human Mast Cells both Positively and Negatively: Possible Roles in Pregnancy and Cancer Metastasis. Int. J. Mol. Sci. 2020, 21, 954. https://doi.org/10.3390/ijms21030954

AMA Style

Kataoka TR, Ueshima C, Hirata M, Minamiguchi S, Haga H. Killer Immunoglobulin-Like Receptor 2DL4 (CD158d) Regulates Human Mast Cells both Positively and Negatively: Possible Roles in Pregnancy and Cancer Metastasis. International Journal of Molecular Sciences. 2020; 21(3):954. https://doi.org/10.3390/ijms21030954

Chicago/Turabian Style

Kataoka, Tatsuki R., Chiyuki Ueshima, Masahiro Hirata, Sachiko Minamiguchi, and Hironori Haga. 2020. "Killer Immunoglobulin-Like Receptor 2DL4 (CD158d) Regulates Human Mast Cells both Positively and Negatively: Possible Roles in Pregnancy and Cancer Metastasis" International Journal of Molecular Sciences 21, no. 3: 954. https://doi.org/10.3390/ijms21030954

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