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Brain-Derived Neurotrophic Factor and Diabetes

Department of Internal Medicine and Diabetology, Poznan University of Medical Sciences, ul. Mickiewicza 2, 60-834 Poznań, Poland
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(3), 841;
Received: 26 December 2019 / Revised: 21 January 2020 / Accepted: 27 January 2020 / Published: 28 January 2020
(This article belongs to the Special Issue Brain-Derived Neurotrophic Factor 2020)
Diabetes and its chronic complications still represent a great clinical problem, despite improvements made in the diagnosis and treatment of the disease. People with diabetes have a much higher risk of impaired brain function and psychiatric disorders. Neurotrophins are factors that protect neuronal tissue and improve the function of the central nervous system, and among them is brain-derived neurotrophic factor (BDNF). The level and function of BDNF in diabetes seems to be disturbed by and connected with the presence of insulin resistance. On the other hand, there is evidence for the highly beneficial impact of physical activity on brain function and BDNF level. However, it is not clear if this protective phenomenon works in the presence of diabetes. In this review, we summarize the current available research on this topic and find that the results of published studies are ambiguous. View Full-Text
Keywords: brain-derived neurotrophic factor (BDNF); neurotrophins; diabetes mellitus; physical activity; neuroprotection; insulin resistance brain-derived neurotrophic factor (BDNF); neurotrophins; diabetes mellitus; physical activity; neuroprotection; insulin resistance
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MDPI and ACS Style

Rozanska, O.; Uruska, A.; Zozulinska-Ziolkiewicz, D. Brain-Derived Neurotrophic Factor and Diabetes. Int. J. Mol. Sci. 2020, 21, 841.

AMA Style

Rozanska O, Uruska A, Zozulinska-Ziolkiewicz D. Brain-Derived Neurotrophic Factor and Diabetes. International Journal of Molecular Sciences. 2020; 21(3):841.

Chicago/Turabian Style

Rozanska, Olga; Uruska, Aleksandra; Zozulinska-Ziolkiewicz, Dorota. 2020. "Brain-Derived Neurotrophic Factor and Diabetes" Int. J. Mol. Sci. 21, no. 3: 841.

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