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Open AccessReview
Peer-Review Record

Mutual Two-Way Interactions of Curcumin and Gut Microbiota

Int. J. Mol. Sci. 2020, 21(3), 1055; https://doi.org/10.3390/ijms21031055
Reviewer 1: Anonymous
Reviewer 2: Anonymous
Int. J. Mol. Sci. 2020, 21(3), 1055; https://doi.org/10.3390/ijms21031055
Received: 19 January 2020 / Revised: 29 January 2020 / Accepted: 3 February 2020 / Published: 5 February 2020
(This article belongs to the Special Issue Curcumin in Health and Disease: New Knowledge)

Round 1

Reviewer 1 Report

The manuscript submitted to IJMS (ijms-707750) is a review concerning the potential interactions of curcumin and gut microbiota. In general, it is well-written and organized paper. However, it is required to provide the structures of curcumin and its metabolites, or even a proposal of transformation pathways of curcumin. There was no comment on the class of compounds which curcumin belong to. In addition, any introduction about sources (plant materials, food) is necessary.

In the section 3. Please provide more information about concentrations (differences) of compound used in the referred studies, e.g. L. 115 „activity of low dose curcumin”. What was the low concentration? More details of studies are needed.

299-303 Please provide any references.

More references concerning curcumin are required for this review manuscript.

Author Response

Reviewer 1. The manuscript submitted to IJMS (ijms-707750) is a review concerning the potential interactions of curcumin and gut microbiota. In general, it is well-written and organized paper. However, it is required to provide the structures of curcumin and its metabolites, or even a proposal of transformation pathways of curcumin. There was no comment on the class of compounds which curcumin belong to. In addition, any introduction about sources (plant materials, food) is necessary.

Done. All changes in red.

In the section 3. Please provide more information about concentrations (differences) of compound used in the referred studies, e.g. L. 115 „activity of low dose curcumin”. What was the low concentration? More details of studies are needed.

Done

299-303 Please provide any references.

Done.

More references concerning curcumin are required for this review manuscript.

We added seven.

Reviewer 2 Report

The  manuscript is suitable for publication.

Author Response

Reviewer 2.

The  manuscript is suitable for publication.

Thanks.

Round 2

Reviewer 1 Report

L. 323 -L. 332

This paragraph also requires references.

Figures 1 and 2: Please change the structures according to the requirements to make them standardized.

 

Author Response

We did suggested changes.

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