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Article

Comparative Analysis of ROS Network Genes in Extremophile Eukaryotes

by 1,*, 1,2,3 and 1,4
1
Department Bioinformatics and Mathematical Modelling, Center of Plant Systems Biology and Biotechnology, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria
2
Bioinformatics, Institute of Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476 Potsdam-Golm, Germany
3
Systems Biology and Mathematical Modelling Group, Max Planck Institute of Molecular Plant Physiology, Am Mühlenberg 1, 14476 Potsdam-Golm, Germany
4
Department of Plant Physiology and Molecular Biology, Plovdiv University, 24 Tsar Assen str., 4000 Plovdiv, Bulgaria
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(23), 9131; https://doi.org/10.3390/ijms21239131
Received: 28 October 2020 / Revised: 27 November 2020 / Accepted: 29 November 2020 / Published: 30 November 2020
The reactive oxygen species (ROS) gene network, consisting of both ROS-generating and detoxifying enzymes, adjusts ROS levels in response to various stimuli. We performed a cross-kingdom comparison of ROS gene networks to investigate how they have evolved across all Eukaryotes, including protists, fungi, plants and animals. We included the genomes of 16 extremotolerant Eukaryotes to gain insight into ROS gene evolution in organisms that experience extreme stress conditions. Our analysis focused on ROS genes found in all Eukaryotes (such as catalases, superoxide dismutases, glutathione reductases, peroxidases and glutathione peroxidase/peroxiredoxins) as well as those specific to certain groups, such as ascorbate peroxidases, dehydroascorbate/monodehydroascorbate reductases in plants and other photosynthetic organisms. ROS-producing NADPH oxidases (NOX) were found in most multicellular organisms, although several NOX-like genes were identified in unicellular or filamentous species. However, despite the extreme conditions experienced by extremophile species, we found no evidence for expansion of ROS-related gene families in these species compared to other Eukaryotes. Tardigrades and rotifers do show ROS gene expansions that could be related to their extreme lifestyles, although a high rate of lineage-specific horizontal gene transfer events, coupled with recent tetraploidy in rotifers, could explain this observation. This suggests that the basal Eukaryotic ROS scavenging systems are sufficient to maintain ROS homeostasis even under the most extreme conditions. View Full-Text
Keywords: ROS; extremotolerance; resurrection plants ROS; extremotolerance; resurrection plants
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MDPI and ACS Style

Lyall, R.; Nikoloski, Z.; Gechev, T. Comparative Analysis of ROS Network Genes in Extremophile Eukaryotes. Int. J. Mol. Sci. 2020, 21, 9131. https://doi.org/10.3390/ijms21239131

AMA Style

Lyall R, Nikoloski Z, Gechev T. Comparative Analysis of ROS Network Genes in Extremophile Eukaryotes. International Journal of Molecular Sciences. 2020; 21(23):9131. https://doi.org/10.3390/ijms21239131

Chicago/Turabian Style

Lyall, Rafe, Zoran Nikoloski, and Tsanko Gechev. 2020. "Comparative Analysis of ROS Network Genes in Extremophile Eukaryotes" International Journal of Molecular Sciences 21, no. 23: 9131. https://doi.org/10.3390/ijms21239131

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