Next Article in Journal
Identifying Cancer-Relevant Mutations in the DLC START Domain Using Evolutionary and Structure-Function Analyses
Next Article in Special Issue
The 14-3-3 Proteins as Important Allosteric Regulators of Protein Kinases
Previous Article in Journal
5-Nitro-2,4-Dichloropyrimidine as an Universal Model for Low-Energy Electron Processes Relevant for Radiosensitization
Previous Article in Special Issue
Advances in Understanding TKS4 and TKS5: Molecular Scaffolds Regulating Cellular Processes from Podosome and Invadopodium Formation to Differentiation and Tissue Homeostasis
 
 
Review

The Role of RIPK1 and RIPK3 in Cardiovascular Disease

Department of Surgery, Division of Vascular Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(21), 8174; https://doi.org/10.3390/ijms21218174
Received: 24 September 2020 / Revised: 29 October 2020 / Accepted: 29 October 2020 / Published: 31 October 2020
(This article belongs to the Special Issue Protein Kinases: Function, Substrates, and Implication in Diseases)
Cardiovascular diseases, including peripheral arterial and venous disease, myocardial infarction, and stroke, are the number one cause of death worldwide annually. In the last 20 years, the role of necroptosis, a newly identified form of regulated necrotic cell death, in cardiovascular disease has come to light. Specifically, the damaging role of two kinase proteins pivotal in the necroptosis pathway, Receptor Interacting Protein Kinase 1 (RIPK1) and Receptor Interacting Protein Kinase 3 (RIPK3), in cardiovascular disease has become a subject of great interest and importance. In this review, we provide an overview of the current evidence supporting a pathologic role of RIPK1 and RIPK3 in cardiovascular disease. Moreover, we highlight the evidence behind the efficacy of targeted RIPK1 and RIPK3 inhibitors in the prevention and treatment of cardiovascular disease. View Full-Text
Keywords: RIPK1; RIPK3; necroptosis; atherosclerosis; stroke; myocardial infarction; abdominal aortic aneurysm; venous thrombosis RIPK1; RIPK3; necroptosis; atherosclerosis; stroke; myocardial infarction; abdominal aortic aneurysm; venous thrombosis
Show Figures

Figure 1

MDPI and ACS Style

DeRoo, E.; Zhou, T.; Liu, B. The Role of RIPK1 and RIPK3 in Cardiovascular Disease. Int. J. Mol. Sci. 2020, 21, 8174. https://doi.org/10.3390/ijms21218174

AMA Style

DeRoo E, Zhou T, Liu B. The Role of RIPK1 and RIPK3 in Cardiovascular Disease. International Journal of Molecular Sciences. 2020; 21(21):8174. https://doi.org/10.3390/ijms21218174

Chicago/Turabian Style

DeRoo, Elise, Ting Zhou, and Bo Liu. 2020. "The Role of RIPK1 and RIPK3 in Cardiovascular Disease" International Journal of Molecular Sciences 21, no. 21: 8174. https://doi.org/10.3390/ijms21218174

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop