Transcriptional Regulation of Inflammasomes
Abstract
:1. Introduction
2. Overview of Inflammasome Complexes
3. Overview of Transcription Regulation
4. Transcriptional Regulation of Inflammasome Sensors
4.1. NLRP1
4.2. NLRP3
4.3. NAIP and NLRC4
4.4. AIM2
4.5. Pyrin
5. Transcriptional Regulation of ASC
6. Transcriptional Regulation of Inflammatory Caspases
6.1. Caspase-1
6.2. Caspase-4
6.3. Caspase-11
6.4. Caspase-5
7. Transcriptional Regulation of Downstream Targets
7.1. GSDMD
7.2. IL-18 and IL-18BP
7.3. IL-1b and IL-1RA
7.3.1. Roles of the Lineage-Specific/Pioneer TFs PU.1 and C/EBPβ
7.3.2. Signal-Dependent TFs (NF-κB)
7.3.3. Metabolic Regulation of IL1b
7.3.4. Negative Regulation of IL1b
7.3.5. IL1b Regulation in T Cells
7.3.6. IL1b Regulation in DCs
7.3.7. IL1RN
8. Conclusions
Funding
Conflicts of Interest
Abbreviations
AhR | Aryl hydrocarbon receptor |
AIM2 | Absent in melanoma 2 |
AP-1 | Activator protein-1 |
ARE | Antioxidant responsive element |
ASC | Apoptosis-associated speck-like protein containing a card |
ATF | Activating transcription factor |
BLIMP1 | B lymphocyte-induced maturation protein-1 |
BMDM | Bone marrow-derived macrophage |
BCL6 | B cell lymphoma 6 |
Brd4 | Bromodomain-containing protein 4 |
CHOP | C/ebp homologous protein |
CRE | Camp-response element |
CREB | Camp response element-binding protein |
DC | Dendritic cell |
DSS | Dextran sodium sulfate |
EBV | Epstein–Barr virus |
EICE | Ets-irf composite element |
ENU | N-ethyl-n-nitrosourea |
ERV | Endogenous retrovirus |
ETS | Erythroblast transformation specific |
GAS | Gamma-activated site |
GFI1 | Growth factor independence 1 |
GRE1 | Gli-responsive element |
HAMPs | Homeostasis-altering molecular processes |
HAT | Histone acetyl transferase |
HIF1α | Hypoxia-inducible factor 1α |
HRE | Hypoxia response element |
IFNAR | Interferon-α/β receptor |
IRE-1 | Inositol-requiring enzyme 1 |
IRF | Interferon regulatory factor |
ISRE | Ifn-stimulated response element |
LTR | Long terminal repeat |
NAIP | Neuronal apoptosis inhibitory protein |
NFAT5 | Nuclear factor of activated t cells 5 |
NF-κB | Nuclear factor κb |
NLR | Nucleotide-binding domain and leucine-rich repeat containing |
NLRP | Nlr family pyrin domain containing |
Nod2 | Nucleotide-binding oligomerization domain 2 |
NR1D1 | Nuclear receptor subfamily 1 group d member 1 |
Nrf2 | Nf-e2-related factor 2 |
ORE | Osmotic response element |
PAMP | Pathogen-associated molecular pattern |
PARP1 | Poly [ADP-ribose] polymerase 1 |
PERK | Pkr-like er protein kinase |
P-TEFb SBE | Positive transcription elongation factor b STAT-Binding Element |
SREBP-1a | Sterol regulatory element binding protein-1a |
STAT1 | Signal Transducer and Activator of Transcription 1 |
SWI/SNF | Switch/sucrose nonfermenting |
TCA | Tricarboxylic acid |
TF | Transcription factor |
TLR | Toll-like receptor |
TNF | Tumor necrosis factor |
TSS | Transcription start site |
UPR | Unfolded protein response |
XRE | Xenobiotic response elements |
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TF | Context | Target | Species | Outcome |
---|---|---|---|---|
AhR | Xenobiotics, metabolites | Nlrp3 | m | Anti-inflammatory |
ATF4 | ER stress | NLRP1 | h | Pro-inflammatory |
BLIMP1 | Human steady state | AIM2 | h | Negative regulation |
C/EBPβ | Cell differentiation | MEFV, IL1B, IL1RN | h | Cell-specific expression |
CHOP | ER stress | Casp11 | m | LPS-induced lung inflammation |
CREB | PGE2 signaling | IL1B | h | Pro-inflammatory |
GFI1 | Negative feedback loop | Nlrp3 | m | Anti-inflammatory |
HIF1α | Metabolism/Hypoxia | IL1B | h, m | Pro-inflammatory |
IRF1 | IFN-Υ treatment | CASP1 | h, m | Pro-inflammatory |
IRF1 | IFN-Υ treatment | IL18BP | h | Anti-inflammatory |
IRF1/2 | IFN-Υ treatment | AIM2 | h | Pro-inflammatory |
IRF2 | Steady state | CASP4 | h | Inflammasome competence |
IRF2 | Steady state | GSDMD | h, m | Inflammasome competence |
IRF4 | cDC1-steady state | Nlrc4, Il1b, Pycard | m | Antigen presentation |
IRF8 | cDC2-steady state | Nlrp3, Nlrc4, Pycard, Il1b | m | Antigen presentation |
IRF8 | BMDM-steady state | Naip2, 5, 6, Nlrc4 | m | Resistance to Salmonella |
IRF8 | EBV + lymphoblastoid cells | CASP1 | h | EBV lytic cycle |
ISGF3 | type I IFN response | Il18 | m | LPS-mediated induction |
LXRα | Metabolism | IL1B | h | Pro-inflammatory |
NF-κB | Pro-inflammatory signals | NLRP3, MEFV, CASP4, CASP5, Casp11, Gsdmd, IL18, IL1B, IL1RN | h, m | Kinetics of inflammasome response |
NFAT5 | Osmotic stress | Nlrp3 | m | Pro-inflammatory |
NR1D1 | Circadian clock | Nlrp3 | m | Circadian oscillation |
NRF2 | Oxidative stress | Il1b | m | Pro-inflammatory |
p53 | DNA damage | Casp11, CASP1, NLRC4 | m, h | Pro-inflammatory |
PU.1 | Cell differentiation | IL-18, IL1B, IL1RN | h | Cell-specific expression |
SREBP-1A | NF-κB activation | Nlrp1a | m | Metabolic inflammation |
STAT1 | IFN-Υ treatment | AIM2 | h | Induction |
STAT1 | IFN-Υ treatment | IL18BP | h | Anti-inflammatory |
STAT3 | IL-10, IL-20R family | Il1b | m | Anti-inflammatory |
STAT3 | IL-21 in DC | Il1b | m | Resistance to pneumonia Virus of mice |
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Cornut, M.; Bourdonnay, E.; Henry, T. Transcriptional Regulation of Inflammasomes. Int. J. Mol. Sci. 2020, 21, 8087. https://doi.org/10.3390/ijms21218087
Cornut M, Bourdonnay E, Henry T. Transcriptional Regulation of Inflammasomes. International Journal of Molecular Sciences. 2020; 21(21):8087. https://doi.org/10.3390/ijms21218087
Chicago/Turabian StyleCornut, Maxence, Emilie Bourdonnay, and Thomas Henry. 2020. "Transcriptional Regulation of Inflammasomes" International Journal of Molecular Sciences 21, no. 21: 8087. https://doi.org/10.3390/ijms21218087