Cardiolipin, the Mitochondrial Signature Lipid: Implication in Cancer
Abstract
:1. Introduction
2. Cardiolipin Metabolism
3. Role of CL in Metabolic Reprogramming
4. Role of CL in Mitochondrial Quality Control
5. Role of CL in Apoptosis
6. Conclusions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
ADR | Adriamycin |
ALCAT1 | Acyl-CoA:lysocardiolipin acyltransferase |
ATP | Adenosine triphosphate |
BAK | Bcl-2 antagonist or killer |
BAX | Bcl-2 associated X protein |
Bcl-2 | B-cell lymphoma-2 |
BID | BH3 interacting domain death agonist |
CDP-DG | Cytidine diphosphate diacylglycerol |
CL | Cardiolipin |
CML | Chronic myeloid leukemia |
CRLS1 | Cardiolipin synthase 1 |
CytC | Cytochrome C |
DOX | Doxorubicin |
DRP1 | Dynamin-related protein 1 |
ETC | Electron transfer chain |
ER | Endoplasmic reticulum |
FADH2 | Flavin adenine dinucleotide (reduced) |
G3P | Glycerol-3 phosphate |
HADHA | Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha |
HCC | Hepatocellular carcinoma |
IMM | Inner mitochondria membrane |
JNK | c-Jun N-terminal kinase |
LC3 | Light chain 3 protein |
MAM | Mitochondria-associated membrane |
MAPK | Mitogen-activated protein kinases |
Mfn | Mitofusin protein |
MICOS | Mitochondrial contact site and cristae organizing system |
MLCL | Monolyso-cardiolipin |
MLCLAT1 | Monolyso-cardiolipin acyl transferase 1 |
NADH | Nicotinamide adenine dinucleotide (reduced) |
NDPK-D | Nucleoside diphosphate kinase D |
NSCLC | Non-small cell lung cancer |
OMM | Outer mitochondria membrane |
OPA-1 | Optic atrophy-1 |
OXPHOS | Oxidative phosphorylation system |
P38 | P38 Mitogen-activated protein kinases signaling pathway |
PA | Phosphatidic acid |
PC | Phosphatidyl choline |
PE | Phosphatidyl ethanolamine |
PG | Phosphatidyl glycerol |
PGP | Phosphatidyl glycerol phosphate |
PGPP1 | Phosphatidyl glycerophosphate phosphatase 1 |
Pgs1 | Phosphatidyl glycerophosphate synthase 1 |
PPM1A | Protein phosphatase, Mg2+/Mn2+ dependent 1A |
PTPRR | Protein tyrosine phosphatase receptor type R |
TCA cycle | Tricarboxylic acid cycle |
UCP3 | Mitochondrial uncoupling protein 3 |
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Ahmadpour, S.T.; Mahéo, K.; Servais, S.; Brisson, L.; Dumas, J.-F. Cardiolipin, the Mitochondrial Signature Lipid: Implication in Cancer. Int. J. Mol. Sci. 2020, 21, 8031. https://doi.org/10.3390/ijms21218031
Ahmadpour ST, Mahéo K, Servais S, Brisson L, Dumas J-F. Cardiolipin, the Mitochondrial Signature Lipid: Implication in Cancer. International Journal of Molecular Sciences. 2020; 21(21):8031. https://doi.org/10.3390/ijms21218031
Chicago/Turabian StyleAhmadpour, Seyedeh Tayebeh, Karine Mahéo, Stéphane Servais, Lucie Brisson, and Jean-François Dumas. 2020. "Cardiolipin, the Mitochondrial Signature Lipid: Implication in Cancer" International Journal of Molecular Sciences 21, no. 21: 8031. https://doi.org/10.3390/ijms21218031