Next Article in Journal
Mathematical Connection between Short Telomere Induced Senescence Calculation and Mortality Rate Data
Next Article in Special Issue
MYC Targets Scores Are Associated with Cancer Aggressiveness and Poor Survival in ER-Positive Primary and Metastatic Breast Cancer
Previous Article in Journal
Proteomic Profiling of Two Distinct Populations of Extracellular Vesicles Isolated from Human Seminal Plasma
Previous Article in Special Issue
New Insights into Therapy-Induced Progression of Cancer
Review

Neurobiology of Cancer: The Role of β-Adrenergic Receptor Signaling in Various Tumor Environments

1
Institute of Physiology, Faculty of Medicine, Comenius University, 813 72 Bratislava, Slovakia
2
Biomedical Research Center, Institute of Experimental Endocrinology, Slovak Academy of Sciences, 814 39 Bratislava, Slovakia
3
Institute of Microbiology, Faculty of Medicine, Comenius University, 811 08 Bratislava, Slovakia
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(21), 7958; https://doi.org/10.3390/ijms21217958
Received: 2 October 2020 / Revised: 21 October 2020 / Accepted: 26 October 2020 / Published: 26 October 2020
(This article belongs to the Special Issue Attacking Cancer Progression and Metastasis)
The development and progression of cancer depends on both tumor micro- and macroenvironments. In addition, psychosocial and spiritual “environments” might also affect cancer. It has been found that the nervous system, via neural and humoral pathways, significantly modulates processes related to cancer at the level of the tumor micro- and macroenvironments. The nervous system also mediates the effects of psychosocial and noetic factors on cancer. Importantly, data accumulated in the last two decades have clearly shown that effects of the nervous system on cancer initiation, progression, and the development of metastases are mediated by the sympathoadrenal system mainly via β-adrenergic receptor signaling. Here, we provide a new complex view of the role of β-adrenergic receptor signaling within the tumor micro- and macroenvironments as well as in mediating the effects of the psychosocial and spiritual environments. In addition, we describe potential preventive and therapeutic implications. View Full-Text
Keywords: β-blockers; cancer; epinephrine; macroenvironment; microenvironment; norepinephrine; psychosocial factors; spirituality; stress; sympathoadrenal system β-blockers; cancer; epinephrine; macroenvironment; microenvironment; norepinephrine; psychosocial factors; spirituality; stress; sympathoadrenal system
Show Figures

Graphical abstract

MDPI and ACS Style

Mravec, B.; Horvathova, L.; Hunakova, L. Neurobiology of Cancer: The Role of β-Adrenergic Receptor Signaling in Various Tumor Environments. Int. J. Mol. Sci. 2020, 21, 7958. https://doi.org/10.3390/ijms21217958

AMA Style

Mravec B, Horvathova L, Hunakova L. Neurobiology of Cancer: The Role of β-Adrenergic Receptor Signaling in Various Tumor Environments. International Journal of Molecular Sciences. 2020; 21(21):7958. https://doi.org/10.3390/ijms21217958

Chicago/Turabian Style

Mravec, Boris, Lubica Horvathova, and Luba Hunakova. 2020. "Neurobiology of Cancer: The Role of β-Adrenergic Receptor Signaling in Various Tumor Environments" International Journal of Molecular Sciences 21, no. 21: 7958. https://doi.org/10.3390/ijms21217958

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop