MYC in Brain Development and Cancer
Department of Cancer Biology and Therapeutics, The John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2600, Australia
*
Author to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(20), 7742; https://doi.org/10.3390/ijms21207742
Received: 20 September 2020 / Revised: 16 October 2020 / Accepted: 16 October 2020 / Published: 20 October 2020
(This article belongs to the Special Issue Myc Function and Regulation)
The MYC family of transcriptional regulators play significant roles in animal development, including the renewal and maintenance of stem cells. Not surprisingly, given MYC’s capacity to promote programs of proliferative cell growth, MYC is frequently upregulated in cancer. Although members of the MYC family are upregulated in nervous system tumours, the mechanisms of how elevated MYC promotes stem cell-driven brain cancers is unknown. If we are to determine how increased MYC might contribute to brain cancer progression, we will require a more complete understanding of MYC’s roles during normal brain development. Here, we evaluate evidence for MYC family functions in neural stem cell fate and brain development, with a view to better understand mechanisms of MYC-driven neural malignancies.
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Keywords:
MYC; brain development; neural stem cells; brain cancer
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MDPI and ACS Style
Zaytseva, O.; Kim, N.-h.; Quinn, L.M. MYC in Brain Development and Cancer. Int. J. Mol. Sci. 2020, 21, 7742. https://doi.org/10.3390/ijms21207742
AMA Style
Zaytseva O, Kim N-h, Quinn LM. MYC in Brain Development and Cancer. International Journal of Molecular Sciences. 2020; 21(20):7742. https://doi.org/10.3390/ijms21207742
Chicago/Turabian StyleZaytseva, Olga; Kim, Nan-hee; Quinn, Leonie M. 2020. "MYC in Brain Development and Cancer" Int. J. Mol. Sci. 21, no. 20: 7742. https://doi.org/10.3390/ijms21207742
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