Maresin 1, a Proresolving Lipid Mediator, Ameliorates Liver Ischemia-Reperfusion Injury and Stimulates Hepatocyte Proliferation in Sprague-Dawley Rats
Abstract
:1. Introduction
2. Results
3. Discussion
4. Materials and Methods
4.1. Animals
4.2. Model of Partial Ischemia-Reperfusion (IR) Injury
4.3. Measurement of Serum Parameters
4.4. Histopathological Examination
4.5. Immunofluorescense Staining
4.6. Western Blot Analysis
4.7. Statistical Analysis
Author Contributions
Funding
Conflicts of Interest
Abbreviations
IR | ischemia-reperfusion |
ROS | reactive oxygen species |
KCs | Küpffer Cells |
PUFA | Polyunsaturated fatty acids |
EPA | eicosapentaenoic acid |
DHA | docosahexaenoic acid |
MaR1 | maresin 1 |
MAI | mitotic activity index |
H&E | hematoxylin-eosin |
ALT | alanine aminotransferase |
AST | aspartate aminotransferase |
SD | standard deviation |
PH | partial hepatectomy |
HCC | hepatocellular carcinoma |
ER | endoplasmic reticulum |
References
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Soto, G.; Rodríguez, M.J.; Fuentealba, R.; Treuer, A.V.; Castillo, I.; González, D.R.; Zúñiga-Hernández, J. Maresin 1, a Proresolving Lipid Mediator, Ameliorates Liver Ischemia-Reperfusion Injury and Stimulates Hepatocyte Proliferation in Sprague-Dawley Rats. Int. J. Mol. Sci. 2020, 21, 540. https://doi.org/10.3390/ijms21020540
Soto G, Rodríguez MJ, Fuentealba R, Treuer AV, Castillo I, González DR, Zúñiga-Hernández J. Maresin 1, a Proresolving Lipid Mediator, Ameliorates Liver Ischemia-Reperfusion Injury and Stimulates Hepatocyte Proliferation in Sprague-Dawley Rats. International Journal of Molecular Sciences. 2020; 21(2):540. https://doi.org/10.3390/ijms21020540
Chicago/Turabian StyleSoto, Gonzalo, María José Rodríguez, Roberto Fuentealba, Adriana V. Treuer, Iván Castillo, Daniel R. González, and Jessica Zúñiga-Hernández. 2020. "Maresin 1, a Proresolving Lipid Mediator, Ameliorates Liver Ischemia-Reperfusion Injury and Stimulates Hepatocyte Proliferation in Sprague-Dawley Rats" International Journal of Molecular Sciences 21, no. 2: 540. https://doi.org/10.3390/ijms21020540