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Open AccessArticle

Impaired Glycolysis Promotes Alcohol Exposure-Induced Apoptosis in HEI-OC1 Cells via Inhibition of EGFR Signaling

1
Department of Otorhinoaryngology-Head and Neck Surgery, College of Medicine, Soonchunhyang University, Cheonan-si, Chungcheongnam-do 31151, Korea
2
Department of Integrated Biomedical Science, Soonchunhyang Institute of Medi-bio Science (SIMS), Soonchunhyang University, Cheonan-si, Chungcheongnam-do 31151, Korea
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(2), 476; https://doi.org/10.3390/ijms21020476
Received: 7 January 2020 / Accepted: 10 January 2020 / Published: 11 January 2020
(This article belongs to the Section Molecular Biology)
Glucose metabolism is an important metabolic pathway in the auditory system. Chronic alcohol exposure can cause metabolic dysfunction in auditory cells during hearing loss. While alcohol exposure has been linked to hearing loss, the mechanism by which impaired glycolysis promotes cytotoxicity and cell death in auditory cells remains unclear. Here, we show that the inhibition of epidermal growth factor receptor (EGFR)-induced glycolysis is a critical mechanism for alcohol exposure-induced apoptosis in HEI-OC1 cells. The cytotoxicity via apoptosis was significantly increased by alcohol exposure in HEI-OC1 cells. The glycolytic activity and the levels of hexokinase 1 (HK1) were significantly suppressed by alcohol exposure in HEI-OC1 cells. Mechanistic studies showed that the levels of EGFR and AKT phosphorylation were reduced by alcohol exposure in HEI-OC1 cells. Notably, HK1 expression and glycolytic activity was suppressed by EGFR inhibition in HEI-OC1 cells. These results suggest that impaired glycolysis promotes alcohol exposure-induced apoptosis in HEI-OC1 cells via the inhibition of EGFR signaling. View Full-Text
Keywords: glycolysis; EGFR signaling; apoptosis; alcohol; HEI-OC1 cells glycolysis; EGFR signaling; apoptosis; alcohol; HEI-OC1 cells
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Kang, H.; Choi, S.J.; Park, K.H.; Lee, C.-K.; Moon, J.-S. Impaired Glycolysis Promotes Alcohol Exposure-Induced Apoptosis in HEI-OC1 Cells via Inhibition of EGFR Signaling. Int. J. Mol. Sci. 2020, 21, 476.

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