Next Article in Journal
The Immune Microenvironment in Pancreatic Cancer
Next Article in Special Issue
Hippocampal 2-Arachidonoyl Glycerol Signaling Regulates Time-of-Day- and Stress-Dependent Effects on Rat Short-Term Memory
Previous Article in Journal
Seminal Plasma Transcriptome and Proteome: Towards a Molecular Approach in the Diagnosis of Idiopathic Male Infertility
Previous Article in Special Issue
Endocannabinoid-Epigenetic Cross-Talk: A Bridge toward Stress Coping
Open AccessReview

Neural Stem Cells and Cannabinoids in the Spotlight as Potential Therapy for Epilepsy

1
Instituto de Farmacologia e Neurociências, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal
2
Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(19), 7309; https://doi.org/10.3390/ijms21197309
Received: 10 September 2020 / Revised: 28 September 2020 / Accepted: 30 September 2020 / Published: 3 October 2020
Epilepsy is one of the most common brain diseases worldwide, having a huge burden in society. The main hallmark of epilepsy is the occurrence of spontaneous recurrent seizures, having a tremendous impact on the lives of the patients and of their relatives. Currently, the therapeutic strategies are mostly based on the use of antiepileptic drugs, and because several types of epilepsies are of unknown origin, a high percentage of patients are resistant to the available pharmacotherapy, continuing to experience seizures overtime. Therefore, the search for new drugs and therapeutic targets is highly important. One key aspect to be targeted is the aberrant adult hippocampal neurogenesis (AHN) derived from Neural Stem Cells (NSCs). Indeed, targeting seizure-induced AHN may reduce recurrent seizures and shed some light on the mechanisms of disease. The endocannabinoid system is a known modulator of AHN, and due to the known endogenous antiepileptic properties, it is an interesting candidate for the generation of new antiepileptic drugs. However, further studies and clinical trials are required to investigate the putative mechanisms by which cannabinoids can be used to treat epilepsy. In this manuscript, we will review how cannabinoid-induced modulation of NSCs may promote neural plasticity and whether these drugs can be used as putative antiepileptic treatment. View Full-Text
Keywords: epilepsy; cannabinoids; neural stem cells; adult hippocampal neurogenesis epilepsy; cannabinoids; neural stem cells; adult hippocampal neurogenesis
Show Figures

Figure 1

MDPI and ACS Style

Lourenço, D.M.; Ribeiro-Rodrigues, L.; Sebastião, A.M.; Diógenes, M.J.; Xapelli, S. Neural Stem Cells and Cannabinoids in the Spotlight as Potential Therapy for Epilepsy. Int. J. Mol. Sci. 2020, 21, 7309.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop