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Exosome Composition and Seminal Plasma Proteome: A Promising Source of Biomarkers of Male Infertility
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Seminal Plasma Transcriptome and Proteome: Towards a Molecular Approach in the Diagnosis of Idiopathic Male Infertility

Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy
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Int. J. Mol. Sci. 2020, 21(19), 7308; https://doi.org/10.3390/ijms21197308
Received: 3 September 2020 / Revised: 29 September 2020 / Accepted: 1 October 2020 / Published: 3 October 2020
As the “-omic” technology has largely developed, its application in the field of medical science seems a highly promising tool to clarify the etiology, at least in part, of the so-called idiopathic male infertility. The seminal plasma (SP) is made-up of secretions coming from the male accessory glands, namely epididymis, seminal vesicles, and prostate. It is not only a medium for sperm transport since it is able to modulate the female reproductive environment and immunity, to allow the acquisition of sperm competence, to influence the sperm RNA content, and even embryo development. The aim of this systematic review was to provide an updated and comprehensive description of the main transcripts and proteins reported by transcriptome and proteome studies performed in the human SP of patients with idiopathic infertility, in the attempt of identifying possible candidate molecular targets. We recurrently found that micro RNA (miR)-34, miR-122, and miR-509 are down-regulated in patients with non-obstructive azoospermia (NOA) and oligozoospermia compared with fertile controls. These molecules may represent interesting targets whose predictive role in testicular sperm extraction (TESE) or assisted reproductive techniques (ART) outcome deserves further investigation. Furthermore, according to the available proteomic studies, ECM1, TEX101, lectingalactoside-binding andsoluble 3 binding protein (LGALS3BP) have been reported as accurate predictors of TESE outcome. Interestingly, ECM1 is differently expressed in patients with different ART outcomes. Further prospective, ample-sized studies are needed to validate these molecular targets that will help in the counseling of patients with NOA or undergoing ART. View Full-Text
Keywords: seminal fluid transcriptome; seminal fluid proteome; male idiopathic infertility; oligozoospermia seminal fluid transcriptome; seminal fluid proteome; male idiopathic infertility; oligozoospermia
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MDPI and ACS Style

Cannarella, R.; Barbagallo, F.; Crafa, A.; La Vignera, S.; Condorelli, R.A.; Calogero, A.E. Seminal Plasma Transcriptome and Proteome: Towards a Molecular Approach in the Diagnosis of Idiopathic Male Infertility. Int. J. Mol. Sci. 2020, 21, 7308. https://doi.org/10.3390/ijms21197308

AMA Style

Cannarella R, Barbagallo F, Crafa A, La Vignera S, Condorelli RA, Calogero AE. Seminal Plasma Transcriptome and Proteome: Towards a Molecular Approach in the Diagnosis of Idiopathic Male Infertility. International Journal of Molecular Sciences. 2020; 21(19):7308. https://doi.org/10.3390/ijms21197308

Chicago/Turabian Style

Cannarella, Rossella; Barbagallo, Federica; Crafa, Andrea; La Vignera, Sandro; Condorelli, Rosita A.; Calogero, Aldo E. 2020. "Seminal Plasma Transcriptome and Proteome: Towards a Molecular Approach in the Diagnosis of Idiopathic Male Infertility" Int. J. Mol. Sci. 21, no. 19: 7308. https://doi.org/10.3390/ijms21197308

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