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Open AccessArticle

Superhydrophilic Polyurethane/Polydopamine Nanofibrous Materials Enhancing Cell Adhesion for Application in Tissue Engineering

by Kamil Kopeć 1,*,†, Michał Wojasiński 1,† and Tomasz Ciach 1,2
1
Faculty of Chemical and Process Engineering, Biomedical Engineering Laboratory, Warsaw University of Technology, Waryńskiego 1, 00-645 Warsaw, Poland
2
Centre for Advanced Materials and Technologies CEZAMAT, Warsaw University of Technology, Poleczki 19, 02-822 Warsaw, Poland
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Int. J. Mol. Sci. 2020, 21(18), 6798; https://doi.org/10.3390/ijms21186798
Received: 31 July 2020 / Revised: 14 September 2020 / Accepted: 14 September 2020 / Published: 16 September 2020
(This article belongs to the Special Issue Polymeric Scaffolds: Design, Processing, and Biomedical Application)
The use of nanofibrous materials in the field of tissue engineering requires a fast, efficient, scalable production method and excellent wettability of the obtained materials, leading to enhanced cell adhesion. We proposed the production method of superhydrophilic nanofibrous materials in a two-step process. The process is designed to increase the wettability of resulting scaffolds and to enhance the rate of fibroblast cell adhesion. Polyurethane (PU) nanofibrous material was produced in the solution blow spinning process. Then the PU fibers surface was modified by dopamine polymerization in water solution. Two variants of the modification were examined: dopamine polymerization under atmospheric oxygen (V-I) and using sodium periodate as an oxidative agent (V-II). Hydrophobic PU materials after the treatment became highly hydrophilic, regardless of the modification variant. This effect originates from polydopamine (PDA) coating properties and nanoscale surface structures. The modification improved the mechanical properties of the materials. Materials obtained in the V-II process exhibit superior properties over those from the V-I, and require shorter modification time (less than 30 min). Modifications significantly improved fibroblasts adhesion. The cells spread after 2 h on both PDA-modified PU nanofibrous materials, which was not observed for unmodified PU. Proposed technology could be beneficial in applications like scaffolds for tissue engineering. View Full-Text
Keywords: polydopamine; nanofibers; polyurethane; hydrophilization; tensile properties; fibroblasts; cell adhesion; tissue engineering; scaffolds polydopamine; nanofibers; polyurethane; hydrophilization; tensile properties; fibroblasts; cell adhesion; tissue engineering; scaffolds
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MDPI and ACS Style

Kopeć, K.; Wojasiński, M.; Ciach, T. Superhydrophilic Polyurethane/Polydopamine Nanofibrous Materials Enhancing Cell Adhesion for Application in Tissue Engineering. Int. J. Mol. Sci. 2020, 21, 6798.

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